Recurrent invasive pneumococcal disease in children: underlying clinical conditions, and immunological and microbiological characteristics

PloS One
Laia AlsinaC Muñoz-Almagro

Abstract

Clinical, immunological and microbiological characteristics of recurrent invasive pneumococcal disease (IPD) in children were evaluated, differentiating relapse from reinfection, in order to identify specific risk factors for both conditions. All patients <18 years-old with recurrent IPD admitted to a tertiary-care pediatric center from January 2004 to December 2011 were evaluated. An episode of IPD was defined as the presence of clinical findings of infection together with isolation and/or pneumococcal DNA detection by Real-Time PCR in any sterile body fluid. Recurrent IPD was defined as 2 or more episodes in the same individual at least 1 month apart. Among recurrent IPD, we differentiated relapse (same pneumococcal isolate) from reinfection. 593 patients were diagnosed with IPD and 10 patients died. Among survivors, 23 episodes of recurrent IPD were identified in 10 patients (1.7%). Meningitis was the most frequent form of recurrent IPD (10 episodes/4 children) followed by recurrent empyema (8 episodes/4 children). Three patients with recurrent empyema caused by the same pneumococcal clone ST306 were considered relapses and showed high bacterial load in their first episode. In contrast, all other episodes of recurrent IPD we...Continue Reading

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Citations

Feb 6, 2019·Journal of Clinical Medicine·June-Sung KimWon Young Kim
Aug 8, 2018·BMC Infectious Diseases·Helene A S IngelsHans-Christian Slotved
Jun 21, 2019·The Pediatric Infectious Disease Journal·Laura DarmaunUNKNOWN ACTIV-GPIP Study Group
Oct 22, 2019·Journal of the Pediatric Infectious Diseases Society·Aleix Soler-GarciaAntoni Noguera-Julian

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Methods Mentioned

BETA
PCR
ELISA
PMA
flow cytometry
Dot-Blot
enzyme-linked immunosorbent assay
ELISAs

Software Mentioned

SPSS
Epi

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