PMID: 9426024Jan 13, 1998Paper

Recurrent ischemia after thrombolysis: importance of associated clinical findings. GUSTO-I Investigators. Global Utilization of Streptokinase and t-PA [tissue-plasminogen activator] for Occluded Coronary Arteries

Journal of the American College of Cardiology
A BetriuE J Topol

Abstract

We sought to assess the incidence and clinical relevance of examination data to recurrent ischemia within an international randomized trial. Ischemic symptoms commonly recur after thrombolysis for acute myocardial infarction. Patients (n = 40,848) were prospectively evaluated for recurrent angina and transient electrocardiographic (ECG) or hemodynamic changes. Five groups were developed: Group 1, patients with no signs or symptoms of recurrent ischemia; Group 2, patients with angina only; Group 3, patients with angina and ST segment changes; Group 4, patients with angina and hemodynamic abnormalities; and Group 5, patients with angina, ST segment changes and hemodynamic abnormalities. Baseline clinical and outcome variables were compared among the five groups. Group 1 comprised 32,717 patients, and Groups 2 to 5 comprised 20% of patients (4,488 in Group 2; 3,021 in Group 3; 337 in Group 4; and 285 in Group 5). Patients with recurrent ischemia were more often female, had more cardiovascular risk factors and less often received intravenous heparin. Significantly more extensive and more severe coronary disease, antianginal treatment, angioplasty and coronary bypass surgery were observed as a function of ischemic severity. The 30-d...Continue Reading

Associated Clinical Trials

Citations

Jun 22, 2000·Coronary Artery Disease·G E Lane, D R Holmes
Jan 6, 2006·Srpski arhiv za celokupno lekarstvo·Predrag ErcegMiodrag Rajić
Sep 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Predrag ErcegDragoslav P Milosevic
Mar 26, 2013·Journal of the American Heart Association·Sameer T AminElliott M Antman

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