Recurrent long-lasting tethering reduces BDNF protein levels in the dorsal hippocampus and frontal cortex in pigs

Hormones and Behavior
J De VryF J van der Staay

Abstract

Brain-derived neurotrophic factor (BDNF) signaling has been implicated in the onset of depression and in antidepressant efficacy, although the exact role of this neurotrophin in the pathophysiology of depression remains to be elucidated. Also, the interaction between chronic stress, which may precede depression, corticosteroids and BDNF is not fully understood. The present study aimed at investigating whether long-lasting, recurrent tethering of sows during a period of 1.5 or 4.5 years leads to enduring effects on measures that may be indicative of chronic stress, compared with animals kept in a group housing system ('loose' sows). Immediately after slaughter, the frontal cortex, dorsal and ventral hippocampus were dissected and protein levels of BDNF and its receptors were analyzed and compared with plasma cortisol levels and adrenal weights. Results indicate that tethering stress reduced BDNF protein levels in the dorsal hippocampus and the frontal cortex, but not in the ventral hippocampus. In addition, levels of TrkB, the high affinity receptor for BDNF, were increased in the dorsal hippocampus. Plasma cortisol levels and adrenal weight were increased after tethering. These stress effects on BDNF levels were more pronounced...Continue Reading

References

Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R A DressendörferC J Strasburger
Jan 1, 1971·Brain, Behavior and Evolution·A Siegel, J P Tassoni
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·M B MoserR G Morris
Oct 9, 1999·Neuroscience Research·J WidenfalkP Thorén
Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
Nov 7, 2000·Biological Psychiatry·R S DumanC D'Sa
Apr 5, 2002·Neuron·Eric J NestlerLisa M Monteggia
Jan 1, 1992·The European Journal of Neuroscience·Gisela Barbany, Håkan Persson
Feb 26, 2004·Behavioral Neuroscience·S B McHughD M Bannerman
Sep 3, 2004·The European Journal of Neuroscience·Fabio FumagalliMarco Andrea Riva
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·W C EngelandB K Levay-Young
Jun 3, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henry K TengBarbara L Hempstead
Jun 14, 2005·Psychoneuroendocrinology·Irina A Antonijevic
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Sep 8, 2006·The EMBO Journal·Spartaco SantiMarco Canossa
Apr 25, 2008·The New England Journal of Medicine·Andrea SainiAlfredo Berruti
Jan 20, 2009·Biological Psychiatry·Tania L RothJ David Sweatt
Dec 19, 2009·Cell Death and Differentiation·L BaroncelliL Maffei
Mar 3, 2010·Physiology & Behavior·F Josef van der StaayS Mechiel Korte

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