PMID: 8590962Jan 1, 1996Paper

Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies

European Journal of Endocrinology
J RobertsJ J Walker

Abstract

The aim of this study was to determine whether recurrent miscarriage (three or more miscarriages, no live children) was associated with an increased incidence of autoantibodies. Five groups were enrolled into the study; healthy non-pregnant women, healthy first-trimester pregnant women, women suffering spontaneous abortion, those undergoing termination of pregnancy and those with a previous history of miscarriage. The number of total B cells and the numbers of the antibody producing B cell subset CD5+/CD20+ were determined for each group. Samples were tested for anticardiolipin antibodies, antinuclear antibodies and thyroid microsomal and thyroglobulin antibodies. The results showed that compared to normal pregnancy or spontaneous abortion, recurrent miscarriage was associated with a significant increase in the number of CD5+/20+ positive cells (0.8 +/- 0.3 vs 0.5 +/- 0.1 vs 1.1 +/- 0.3 x 10(8)/l; p < 0.001). These women were also found to have a higher incidence of thyroid antibodies, with four out of the 11 patients being positive for thyroid microsomal antibodies. These results suggest that there may be an association between autoimmunity and recurrent miscarriage.

Citations

Mar 5, 1999·Fertility and Sterility·R WilsonJ J Walker
May 29, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Kris PoppeDaniel Glinoer
Jan 1, 1996·Nutrition Research Reviews·M E Symonds, L Clarke
Jan 5, 2002·Thyroid : Official Journal of the American Thyroid Association·T BagisE S Saygili
Dec 20, 2002·Thyroid : Official Journal of the American Thyroid Association·Kris PoppeBrigitte Velkeniers
Apr 6, 2013·Thyroid : Official Journal of the American Thyroid Association·Flavia MagriLuca Chiovato
Jun 22, 1999·American Journal of Reproductive Immunology : AJRI·L KovácsG Pokorny
Jun 21, 2011·Journal of Thyroid Research·Alex Stagnaro-Green
Jul 13, 2014·Human Reproduction Update·Azure N FaucetteKang Chen
Feb 17, 2007·Clinical Endocrinology·Kris PoppeDaniel Glinoer
Jan 5, 2011·Clinical Endocrinology·Lili Chen, Renming Hu
Aug 18, 2010·American Journal of Reproductive Immunology : AJRI·Na Young KimJoanne Kwak-Kim
Jan 5, 2013·Clinical and Experimental Immunology·T G NguyenJ M Morris
Jan 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ineke KrabbendamHein W Bruinse
May 26, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Alex Stagnaro-Green, Daniel Glinoer
Dec 17, 1998·American Journal of Obstetrics and Gynecology·M S EsplinA Stagnaro-Green
Mar 1, 2008·Expert Review of Endocrinology & Metabolism·Roberto Negro
Mar 1, 2008·Expert Review of Endocrinology & Metabolism·Gerasimos E KrassasAthina Kaprara
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Giampaolo PapiElio Roti
Jan 23, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Roberto Negro, Alex Stagnaro-Green
Mar 22, 2020·American Journal of Reproductive Immunology : AJRI·Jilai XieMin Jin
Jul 13, 2016·Clinical Obstetrics and Gynecology·Maria C KrogAstrid M Kolte
Nov 15, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S DendrinosG Creatsas
Jun 19, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Amir Tabrizipour IravaniMehrshad Abbasi
Apr 11, 2021·American Journal of Reproductive Immunology : AJRI·Hindi E StohlWilliam Stohl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.