Recurrent pericarditis in children: elevated cardiac autoantibodies

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
R Dalla PozzaH Netz

Abstract

Recurrent pericarditis is a rare disease in childhood. Nevertheless, it may represent a challenge to the clinician due to its resistance to anti-inflammatory treatment. The initial etiology often remains unclear; specific laboratory parameters predicting the frequency or severity of the recurrences are lacking. We report on four patients with recurrent pericarditis in whom antimyolemmal antibodies (AMLAs) were detected. A prolonged persistence of IgM-type AMLAs was found in three patients: two of them presented with acute inflammation as the initial event and one with 48 recurrences during 5.5 years. The fourth patient showed a fast conversion from IgM to IgG-type AMLAs after a less acute initial presentation and showed 4 mild recurrences during the 48-month follow-up. We were able to detect AMLAs in four children with recurrent pericarditis. This finding may be attributed to an auto-immunological disease following a first, acute event. We propose the detection of AMLAs in all children with unexplained recurrent pericarditis. Pediatric patients with a persistence of IgM-type AMLAs may face frequent recurrences and should be monitored therefore more closely. In addition, medical treatment may be changed in these patients with a ...Continue Reading

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Citations

Apr 30, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Farbod Sedaghat-HamedaniBenjamin Meder
Feb 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Luca CantariniMassimo Imazio
Jan 9, 2016·The American Journal of Cardiology·Dor LotanYehuda Adler
Mar 5, 2016·Disease Markers·Konstantinos KaratoliosBernhard Maisch
Nov 30, 2010·Pediatric Clinics of North America·Yamini DuraniBrett W Goudie
Aug 15, 2018·Expert Review of Cardiovascular Therapy·Alessandro Galluzzo, Massimo Imazio
Jun 30, 2011·Pediatric Emergency Care·Savithiri RatnapalanLee Benson
Oct 27, 2012·Expert Review of Cardiovascular Therapy·Massimo Imazio
Jul 29, 2016·Journal of Cardiovascular Medicine·Massimo ImazioAlberto Martini

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