Recurrent pericarditis: infectious or autoimmune?

Autoimmunity Reviews
Antonio BrucatoYehuda Adler

Abstract

The etiology and pathogenesis of idiopathic recurrent acute pericarditis (IRAP) remain controversial standing like a bridge that crosses infectious, autoimmune and autoinflammatory pathways. Anything may cause acute pericarditis; Echo-virus, and Coxsackie are the most frequently involved viruses, Mycobacterium tuberculosis and Coxiella burnetii the most common bacteria, but in 85% of cases it remains "idiopathic". Recurrences occur in up to 20-50% of patients. An immuno-mediated pathogenesis is suggested by the presence of pro-inflammatory cytokines in pericardial fluid, the presence of antinuclear autoantibodies (ANA) in sera of the patients, the occurrence of new autoimmune diagnoses and the good response to anti-inflammatory or immunosuppressive therapy. Nonsteroidal anti-inflammatory drugs (NSAIDs) must be used at recommended dosages, till the resolution of symptoms and normalization of C-reactive protein and erythrocyte sedimentation rate. Corticosteroids should be used rarely, at low doses, with an extremely low tapering and with osteoporosis prevention. Colchicine leads to a clinically important and statistically significant benefit, reducing recurrences by 50%. The long term outcome of IRAP is good, without evidence of ...Continue Reading

References

Nov 19, 2004·The New England Journal of Medicine·Richard A Lange, L David Hillis
Jul 11, 2006·The American Journal of Cardiology·Antonio BrucatoDavid H Spodick
Oct 20, 2006·International Journal of Cardiology·Massimo Imazio, Rita Trinchero
May 16, 2007·Circulation·Massimo ImazioRita Trinchero
Jul 31, 2007·Future Microbiology·Pierre-Yves LevyDidier Raoult
Sep 11, 2007·The American Journal of Cardiology·Massimo ImazioRita Trinchero
Jan 24, 2008·Nature Clinical Practice. Cardiovascular Medicine·Massimo ImazioYehuda Adler

❮ Previous
Next ❯

Citations

Feb 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Luca CantariniMassimo Imazio
May 3, 2011·Current Infectious Disease Reports·Massimo Imazio
Dec 21, 2010·Clinical Reviews in Allergy & Immunology·Luca CantariniMauro Galeazzi
Dec 29, 2010·Clinical Reviews in Allergy & Immunology·Udi Nussinovitch, Yehuda Shoenfeld
Jan 6, 2011·Clinical Reviews in Allergy & Immunology·Udi Nussinovitch, Yehuda Shoenfeld
Jan 6, 2011·Clinical Reviews in Allergy & Immunology·Udi Nussinovitch, Yehuda Shoenfeld
Sep 3, 2013·The New England Journal of Medicine·Massimo ImazioUNKNOWN ICAP Investigators
Aug 3, 2012·Heart Failure Reviews·Petar M SeferovićBernhard Maisch
Mar 5, 2016·Disease Markers·Konstantinos KaratoliosBernhard Maisch
Aug 12, 2015·Nature Reviews. Cardiology·Massimo ImazioFiorenzo Gaita
Jun 19, 2012·International Journal of Cardiology·Dimitrios VassilopoulosDimitrios Pectasides
Feb 8, 2011·International Journal of Cardiology·Fabrizio VianelloRenzo Marcolongo
Sep 1, 2009·Autoimmunity Reviews·Siba P RaychaudhuriM Eric Gershwin
Apr 22, 2010·Cardiovascular Therapeutics·Salman Azam, Brian D Hoit
Feb 4, 2014·International Journal of Cardiology·Panagiotis VasileiouDimitrios Vassilopoulos
Sep 29, 2011·Archives of Cardiovascular Diseases·Philippe Meurin, Jean-Yves Tabet
Apr 25, 2016·Current Cardiology Reports·Massimo ImazioPhilippe Charron
Dec 31, 2014·The American Journal of Cardiology·M Chadi AlraiesAllan L Klein
Oct 14, 2014·Autoimmunity Reviews·Luca CantariniDonato Rigante
Mar 29, 2011·La Revue de médecine interne·G Geri, P Cacoub
Mar 13, 2018·Current Opinion in Cardiology·Sophie Van Linthout, Carsten Tschöpe
Sep 22, 2011·Cardiology·George LazarosChristodoulos Stefanadis
May 24, 2019·Circulation Research·Carsten TschöpeSophie Van Linthout
Sep 22, 2011·Expert Review of Cardiovascular Therapy·Massimo Imazio
Oct 27, 2012·Expert Review of Cardiovascular Therapy·Massimo Imazio
Aug 26, 2010·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Apr 23, 2020·European Heart Journal. Acute Cardiovascular Care·Andi RrokuBettina Heidecker
May 23, 2020·Journal of Cardiovascular Translational Research·Ahmed ElsanhourySophie Van Linthout
Jan 17, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Tevfik F Ismail
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Ninaad LasradoJay Reddy
Feb 21, 2021·European Heart Journal. Acute Cardiovascular Care·Andi RrokuBettina Heidecker
Dec 19, 2020·Panminerva Medica·Aldo BonaventuraAntonio Abbate
Feb 24, 2021·Panminerva Medica·Alessandra VecchièAntonio Abbate

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here