Recurrent postinfectious glomerulonephritis: an unusual evolution compatible with C3 glomerulopathy

BMJ Case Reports
Jose Luis Espinosa-FigueroaMercedes Velo-Plaza

Abstract

Acute endocapillary glomerulonephritis, as its name suggests, is a one-time process, which usually resolves within weeks. However, in a small percentage of patients, the disease becomes chronic. In these cases, a deregulation in the alternative complement pathway, which can be caused by mutations or autoantibodies, has been proposed as a pathophysiological mechanism. As a result, the alternative complement pathway remains active after resolution of infection. We report a patient with two episodes of acute renal failure, both times diagnosed by renal biopsy of acute endocapillary glomerulonephritis, with slow recovery after two episodes of low-serum complement C3, haematuria and proteinuria.

References

Apr 5, 2001·The New England Journal of Medicine·M J Walport
Apr 12, 2001·The New England Journal of Medicine·M J Walport
Jul 8, 2010·Nature Reviews. Nephrology·Fadi FakhouriMatthew C Pickering
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Frank BridouxGuy Touchard
Mar 10, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Andrew S BombackGerald B Appel
Oct 3, 2012·Nature Reviews. Nephrology·Andrew S Bomback, Gerald B Appel
Jan 16, 2013·Current Opinion in Nephrology and Hypertension·Carla M Nester, Richard J Smith
Apr 30, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ladan ZandSanjeev Sethi
Nov 1, 2013·Kidney International·Matthew C PickeringH Terence Cook
Mar 6, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sue RichardsUNKNOWN ACMG Laboratory Quality Assurance Committee
May 21, 2015·Journal of the American Society of Nephrology : JASN·Sanjeev SethiFernando C Fervenza
May 21, 2015·Journal of the American Society of Nephrology : JASN·H Terence Cook
Apr 1, 2012·Clinical Kidney Journal·Pilar NozalMargarita López-Trascasa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

© 2022 Meta ULC. All rights reserved