Recurrent potentials in human peripheral sensory nerve: possible evidence of primary afferent depolarization of the spinal cord

Muscle & Nerve
J M ShefnerC Krarup

Abstract

To study slowly conducted components of the orthodromic compound sensory action potential (CSAP), the response evoked at the lateral malleolus in the sural nerve was recorded through near-nerve needles at two to four sites along the nerve at midcalf. When 500 to 2000 responses were averaged at high gain, components with latencies of 30 to 80 ms were often recorded. In contrast to the main component and late components with latencies of less than 15 to 20 ms, the latencies of these extremely late components diminished the closer to the spinal cord that they were recorded. This suggested that the components were conducted antidromically from proximal to distal. This assumption was supported by abolishing the components by local anesthesia of the nerve proximal to the recording electrodes. These antidromic potentials therefore appear to be due to recurrent discharges in the sural nerve. Recurrent discharges were recorded from 65% of 60 subjects (18 normal subjects and 42 patients with peripheral or central nervous system disorders). The latencies of the recurrent discharges allowed conduction to and back from the spinal cord. Although the origin of these potentials remains unknown, we suggest that they are due to dorsal root refle...Continue Reading

References

May 1, 1978·The American Journal of Physiology·F Ramón, J W Moore
Sep 1, 1978·Brain : a Journal of Neurology·F Behse, Buchthal
Jul 1, 1979·Neurology·Z Seltzer, M Devor
Apr 1, 1979·Journal of the Neurological Sciences·G Roth
Apr 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·J DelbekeS J Kopec
Mar 1, 1979·The Journal of Comparative Neurology·L A Langford, R E Coggeshall
Mar 1, 1992·Muscle & Nerve·S H Horowitz, C Krarup
Jun 1, 1991·Muscle & Nerve·J M ShefnerC Krarup
Apr 1, 1985·Journal of the Neurological Sciences·C Krarup, R W Gilliatt
Oct 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·E Stålberg, J V Trontelj
Jan 1, 1971·Brain : a Journal of Neurology·F Buchthal, A Rosenfalck
Jan 1, 1983·Progress in Biophysics and Molecular Biology·E Syková
Oct 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·S TaylorM Verrier
May 1, 1984·The Journal of Comparative Neurology·K Chung, R E Coggeshall
Jan 1, 1961·Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie·J C ECCLES
Feb 1, 1965·Journal of Neurology, Neurosurgery, and Psychiatry·P M FULLERTON, R W GILLIATT
Jan 1, 1962·The Journal of Physiology·J C EcclesW D Willis

❮ Previous
Next ❯

Citations

Oct 29, 2002·Muscle & Nerve·Carlos A LucianoRaphael Schiffmann
Dec 1, 1995·Progress in Neurobiology·R B Stein
May 3, 2006·Progress in Neurobiology·William D Willis
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W Marques Júnior, A A Barreira
Apr 29, 2016·Journal of Neurophysiology·Alan J McComas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
R C RobertsP Butchart
Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology
J D BrookeJ E Misiaszek
© 2021 Meta ULC. All rights reserved