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Recurrent pre-leukemic deletions in myeloid malignancies are the result of DNA double-strand breaks followed by microhomology-mediated end joining

bioRxiv

Jan 2, 2020

Tzah FeldmanLiran I Shlush

Abstract

The mechanisms underlying myeloid malignancies deletions are not well understood, nor is it clear why specific genomic hotspots are predisposed to particular deletions. In the current study we inspected the genomic regions around recurrent deletions in myeloid malignancies, and identifi...read more

Mentioned in this Paper

Gene Expression
ASXL1
DNA Breaks, Double-Stranded
DNA Repair
Gene Deletion
Protein Expression
CALR
Microhomology-Mediated End Joining Repair
DNA, Double-Stranded
Leukemia
7
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Molecular mechanisms of deletions induced as a result of double-strand DNA breaks

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© 2020 Meta ULC. All rights reserved

Recurrent pre-leukemic deletions in myeloid malignancies are the result of DNA double-strand breaks followed by microhomology-mediated end joining

bioRxiv

Jan 2, 2020

Tzah FeldmanLiran I Shlush

DOI: 10.1101/2020.01.01.888610

Abstract

The mechanisms underlying myeloid malignancies deletions are not well understood, nor is it clear why specific genomic hotspots are predisposed to particular deletions. In the current study we inspected the genomic regions around recurrent deletions in myeloid malignancies, and identifi...read more

Mentioned in this Paper

Gene Expression
ASXL1
DNA Breaks, Double-Stranded
DNA Repair
Gene Deletion
Protein Expression
CALR
Microhomology-Mediated End Joining Repair
DNA, Double-Stranded
Leukemia
7

Similar Papers Found In These Feeds

Blood And Marrow Transplantation

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Hematopoetic Stem Cells

Hematopoietic stem cells (HSCs) are the cells that give rise to blood cells of the myeloid and lymphoid lineage during hematopoiesis. HSC transplantation is an established therapeutic option for both malignant and nonmalignant indications. Here is the latest research.

Related Papers

Doklady Akademii nauk SSSR

Molecular mechanisms of deletions induced as a result of double-strand DNA breaks

Doklady Akademii nauk SSSRSeptember 1, 1987
R I SalganikG L Dianov
Molecular Cancer Research : MCR

Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia

Molecular Cancer Research : MCRDecember 10, 2017
Franz Josef GassnerRoland Geisberger
Paper Details
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    We're still populating references for this paper, please check back later.
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