PMID: 6980226Jan 1, 1982Paper

Recurrent pyogenic infections in individuals with absence of the second component of complement

Journal of Clinical Immunology
H A SampsonP J Baker

Abstract

While deficiency of the terminal components of complement (C3-C8) has classically been associated with recurrent pyogenic infections, it has become apparent that C2 deficiency is also associated with recurrent infections in some individuals. The patient presented here had two major pyogenic infections prior to 1 year of age and was found to lack the second component of complement. Studies of alternative complement pathway and humoral and cellular immunity were found to be within normal limits. Family studies suggest an autosomal codominant pattern of inheritance for the C2 defect, which also corresponded to the inheritance of the HLA A10 B18 haplotype. A review of the literature revealed nine other cases of C2-deficient patients with well-documented recurrent infections. In these patients, Streptococcus pneumoniae is the organism most frequently implicated in infectious processes, whether or not their alternative complement pathway is intact.

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Citations

Mar 24, 2004·Trends in Immunology·Aras Kadioglu, Peter W Andrew
Mar 1, 1997·The British Journal of Dermatology·M J Hudson-PeacockN B Simpson
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeremy S BrownMarina Botto
Jan 1, 1984·Critical Reviews in Microbiology·J A Winkelstein
Oct 1, 1986·Pathology·D L Gordon, M K Hostetter
Mar 23, 1987·The American Journal of Medicine·E W GelfandS Ruddy
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jose YusteJeremy S Brown
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ling LuJing-Ren Zhang
Jul 1, 1991·Clinical Microbiology Reviews·J E Figueroa, P Densen

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