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Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

Cell

Nov 25, 2019

Alfredo M ValenciaCigall Kadoch

Abstract

Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain-specific contributions to complex activities is needed to advance mechanistic understanding. Here, we examine the molecul...read more

Mentioned in this Paper

Neuron Differentiation
Study
Conserved Sequence
Genome
Complex (molecular entity)
Drug Substitution
Coiled-Coil Domain
Nucleosome Location
SMARCB1
Site
145
1
3
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Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

Cell

Nov 25, 2019

Alfredo M ValenciaCigall Kadoch

PMID: 31759698

DOI: 10.1016/j.cell.2019.10.044

Abstract

Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain-specific contributions to complex activities is needed to advance mechanistic understanding. Here, we examine the molecul...read more

Mentioned in this Paper

Neuron Differentiation
Study
Conserved Sequence
Genome
Complex (molecular entity)
Drug Substitution
Coiled-Coil Domain
Nucleosome Location
SMARCB1
Site
145
1
3

Related Papers

Paper Details
References
  • References
  • Citations1
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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