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Recurrent somatic mutations in regulatory regions of human cancer genomes

Nature Genetics

Jun 9, 2015

Collin MeltonMichael P Snyder

Abstract

Aberrant regulation of gene expression in cancer can promote survival and proliferation of cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome Atlas (TCGA) for 436 patients from 8 cancer subtypes with ENCODE and other regulatory annotations to identify po...read more

Mentioned in this Paper

Conserved Sequence
Gene Expression Regulation, Neoplastic
The Cancer Genome Atlas
Genome
Regulation of Biological Process
Somatic Mutation
Neoplasms
Promoter
Gene Mutation
TERT gene
85
1
8
437
1
Paper Details
References
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  • Citations67
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  • References32
  • Citations67
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Recurrent somatic mutations in regulatory regions of human cancer genomes

Nature Genetics

Jun 9, 2015

Collin MeltonMichael P Snyder

PMID: 26053494

DOI: 10.1038/ng.3332

Abstract

Aberrant regulation of gene expression in cancer can promote survival and proliferation of cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome Atlas (TCGA) for 436 patients from 8 cancer subtypes with ENCODE and other regulatory annotations to identify po...read more

Mentioned in this Paper

Conserved Sequence
Gene Expression Regulation, Neoplastic
The Cancer Genome Atlas
Genome
Regulation of Biological Process
Somatic Mutation
Neoplasms
Promoter
Gene Mutation
TERT gene
85
1
8
437
1

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Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Mammalian Cell Cycle & Cell Growth Control

Mammalian cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of mammalian cell cycle and growth.

Related Papers

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Highly recurrent TERT promoter mutations in human melanoma

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Paper Details
References
  • References32
  • Citations67
1234
  • References32
  • Citations67
12345...
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