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Recurrent somatic mutations in regulatory regions of human cancer genomes

Nature Genetics

Jul 1, 2015

Collin MeltonMichael P. Snyder

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Abstract

Aberrant regulation of gene expression in cancer can promote survival and proliferation of cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome Atlas (TCGA) for 436 patients from 8 cancer subtypes with ENCODE and other regulatory annotations to identify po...read more

Mentioned in this Paper

Malignant Neoplasms
Conserved Sequence
Early Promoters, Genetic
Gene Expression
Gene Expression Regulation, Neoplastic
Genome
Genome, Human
Neoplasms
Oncogenes
Regulatory Sequences, Nucleic Acid
85
1
8
432
1
Paper Details
References
    • References30
    • Citations59
    • References30
    • Citations59
  • Recurrent somatic mutations in regulatory regions of human cancer genomes

    Nature Genetics

    Jul 1, 2015

    Collin MeltonMichael P. Snyder

    PMID: 26053494

    DOI: 10.1038/ng.3332

    Abstract

    Aberrant regulation of gene expression in cancer can promote survival and proliferation of cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome Atlas (TCGA) for 436 patients from 8 cancer subtypes with ENCODE and other regulatory annotations to identify po...read more

    Mentioned in this Paper

    Malignant Neoplasms
    Conserved Sequence
    Early Promoters, Genetic
    Gene Expression
    Gene Expression Regulation, Neoplastic
    85
    1
    8
    432
    1
    Paper Details
    References
    • References30
    • Citations59
    • References30
    • Citations59
  • Get paper from

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