Abstract
This study investigated a case of spindle cell carcinoma (SpCC) in tongue pathological lesions. The patient experienced a local recurrence and distant metastasis after surgical intervention. Although standard chemotherapy was administered, a granulomatous mass continued to develop. This aggressive growth led to survival of the tumor. Secondary debulking surgery was performed to improve the patient's quality of life at the request of the patient. Using a tissue sample derived from the secondary debulking surgery, we performed an analysis of the tumor's cell surface antigens, differentiation potential, metastatic ability, and inhibition potential by anticancer reagents. In vitro analysis revealed that the cell population grown under adherent culture conditions expressed the mesenchymal stem cell (MSC) markers CD73, CD90, and CD105. The cell line established from this SpCC contained colony-forming unit fibroblasts (CFU-Fs) and exhibited multipotent differentiation into several mesenchymal lineages, including bone, cartilage, and fat. The SpCC cells also displayed vigorous mobilization. These characteristics suggested that they had the differentiation potential of mesenchymal cells, especially MSCs, rather than that of epithelial c...Continue Reading
References
May 1, 1976·Cancer·H Battifora
Aug 15, 1981·Cancer·G S Leventon, H L Evans
Apr 2, 1999·Science·M F PittengerD R Marshak
Mar 28, 2003·The New England Journal of Medicine·Jan CoolsD Gary Gilliland
May 30, 2006·Journal of Clinical Pathology·Ruchika GuptaAshish Kumar Mandal
Aug 23, 2006·Cytotherapy·M DominiciEm Horwitz
Oct 21, 2009·The Journal of Experimental Medicine·Satoru MorikawaYumi Matsuzaki
Aug 13, 2010·Nature·Simón Méndez-FerrerPaul S Frenette
Aug 24, 2010·Head and Neck Pathology·Seethalakshmi ViswanathanS V Kane
Mar 15, 2011·Cancer Cell·Takatsugu IshimotoHideyuki Saya
Jan 16, 2013·Cancer Research·Momoko YoshikawaOsamu Nagano
Sep 21, 2013·Stem Cell Reports·Yo MabuchiYumi Matsuzaki
Dec 7, 2013·Journal of Cellular and Molecular Medicine·Lu HeJian Hong
Oct 30, 2014·Clinical Oral Investigations·Gokulan Ravindran, Halagowder Devaraj
Nov 8, 2014·ELife·Yarden KatzChristopher B Burge
Jan 8, 2015·Head and Neck Pathology·R F WatsonJ S Lewis
Jan 20, 2016·Oncotarget·Fabia FilipelloFabio Grassi
May 15, 2016·Differentiation; Research in Biological Diversity·Takehito OuchiHideyuki Okano