Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells

Journal of Dental Research
T OuchiS Asoda

Abstract

This study investigated a case of spindle cell carcinoma (SpCC) in tongue pathological lesions. The patient experienced a local recurrence and distant metastasis after surgical intervention. Although standard chemotherapy was administered, a granulomatous mass continued to develop. This aggressive growth led to survival of the tumor. Secondary debulking surgery was performed to improve the patient's quality of life at the request of the patient. Using a tissue sample derived from the secondary debulking surgery, we performed an analysis of the tumor's cell surface antigens, differentiation potential, metastatic ability, and inhibition potential by anticancer reagents. In vitro analysis revealed that the cell population grown under adherent culture conditions expressed the mesenchymal stem cell (MSC) markers CD73, CD90, and CD105. The cell line established from this SpCC contained colony-forming unit fibroblasts (CFU-Fs) and exhibited multipotent differentiation into several mesenchymal lineages, including bone, cartilage, and fat. The SpCC cells also displayed vigorous mobilization. These characteristics suggested that they had the differentiation potential of mesenchymal cells, especially MSCs, rather than that of epithelial c...Continue Reading

References

Apr 2, 1999·Science·M F PittengerD R Marshak
May 30, 2006·Journal of Clinical Pathology·Ruchika GuptaAshish Kumar Mandal
Aug 13, 2010·Nature·Simón Méndez-FerrerPaul S Frenette
May 15, 2016·Differentiation; Research in Biological Diversity·Takehito OuchiHideyuki Okano

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BETA
flow cytometry

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SPSS Statistics

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