Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience

Translational Psychiatry
Ravit HadarChristine Winter

Abstract

Depressive symptoms are often accompanied by cognitive impairments and recurrent depressive episodes are discussed as a potential risk for dementia. Especially, stressful life events are considered a potent risk factor for depression. Here, we induced recurrent stress-induced depressive episodes over the life span of rats, followed by cognitive assessment in the symptom-free period. Rats exposed to stress-induced depressive episodes learned faster than control rats. A high degree of stress-induced depressive-like behavior early in the paradigm was a predictor of improved cognitive performance, suggesting induction of resilience. Subsequently, exposure to lorazepam prior to stress-induced depressive episodes and cognitive testing in a nonaversive environment prevented the positive effect. This indicates a beneficial effect of the stress-associated situation, with the existence of individual coping abilities. Altogether, stress may in some have a beneficial effect, yet for those individuals unable to tackle these aversive events, consecutive unpleasant episodes may lead to worse cognitive performance later in life.

References

Jan 1, 1978·Pharmacology, Biochemistry, and Behavior·J F FloodM E Jarvik
Feb 1, 1967·Journal of Comparative and Physiological Psychology·J B Overmier, M E Seligman
Jan 6, 2001·Neuron·M Fava, K S Kendler
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Aug 28, 2001·Brain Research. Brain Research Protocols·B Vollmayr, F A Henn
Apr 2, 2004·The American Journal of Psychiatry·Stephanie CampbellGlenda M MacQueen
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie RidderPeter Gass
Jan 21, 2006·Hippocampus·Jennifer L Warner-Schmidt, Ronald S Duman
Apr 3, 2007·European Archives of Psychiatry and Clinical Neuroscience·Barbara VollmayrFritz A Henn
Apr 23, 2008·Current Protocols in Neuroscience·Gary L Wenk
Dec 17, 2009·Molecular Psychiatry·V K PariharA K Shetty
Feb 4, 2010·Behavioural Brain Research·Thomas EnkelMiriam Schneider
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Oct 5, 2010·Neuroscience and Biobehavioral Reviews·Karen Wager-Smith, Athina Markou
Sep 11, 2012·Neuron·Tamara B FranklinIsabelle M Mansuy
Nov 20, 2012·Reviews in the Neurosciences·Simona CabibValentina Colelli
Mar 2, 2013·Frontiers in Behavioral Neuroscience·Robert C DruganStephen Kent
Mar 13, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lin SuoLin Lu
Jun 14, 2013·Cell and Tissue Research·Barbara Vollmayr, Peter Gass
Dec 5, 2013·Neuroscience and Biobehavioral Reviews·Ian MaharJosé N Nobrega
Jun 3, 2014·Stress : the International Journal on the Biology of Stress·Morgan LucasGal Richter-Levin
May 29, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Piotr GałeckiMichael Maes

❮ Previous
Next ❯

Citations

Feb 8, 2021·Behavioural Brain Research·Ying XueMengqi Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

EthoVision Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.