Recurrent type III membranoproliferative glomerulonephritis after kidney transplantation

Transplantation
J M MoralesG Usera

Abstract

The first well-documented case of recurrent type III membranoproliferative glomerulonephritis after kidney transplantation is reported in this article. A 48-year-old man was admitted to the hospital because of nephrotic syndrome and moderate renal failure. The renal biopsy showed double-contour images at light microscopy. Electron microscopy revealed electron-dense deposits in the mesangium and in both the subepithelial and subendothelial sides of the basement membrane. Subepithelial deposits were sometimes hump-like and produced an irregular disruption of the lamina densa. A diagnosis of type III membranoproliferative glomerulonephritis was suggested. The patient had a rapid decrease in renal function and received dialysis in 3 months. Three years later, he received a cadaveric kidney transplant, and subsequently recovered normal renal function. Proteinuria appeared after 13 months, and a biopsy of the graft demonstrated recurrence of the original disease. Seven years after transplantation, he returned to hemodialysis.

References

May 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A SchwarzF Keller
Feb 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E C JacksonC D West
Nov 1, 1982·Transplantation·J S Cameron
Jul 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E L Ramos, C C Tisher

Citations

Mar 23, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Connie L DavisAlan H Wilkinson
Mar 3, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Anuja JavaD C Brennan
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·John J NearyMichelle P Winn
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·S Chadban

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