Recyclable magnetic nanoparticles grafted with antimicrobial metallopolymer-antibiotic bioconjugates

Biomaterials
Parasmani PageniChuanbing Tang

Abstract

Over-prescription and improper use of antibiotics has led to the emergence of bacterial resistance, posing a major threat to public health. There has been significant interest in the development of alternative therapies and agents to combat antibiotic resistance. We report the preparation of recyclable magnetic iron oxide nanoparticles grafted with charged cobaltocenium-containing metallopolymers by surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. β-Lactam antibiotics were then conjugated with metallopolymers to enhance their vitality against both Gram-positive and Gram-negative bacteria. The enhanced antibacterial activity was a result of synergy of antimicrobial segments that facilitate the inhibition of hydrolysis of antibiotics and local enhancement of antibiotic concentration on a nanoparticle surface. These magnetic nanoparticles can be recycled numerous times without losing the initial antimicrobial potency. Studies suggested negligible toxicity of metallopolymer-grafted nanoparticles to red blood cells and minimal tendency to induce resistance in bacteria.

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Citations

Oct 20, 2018·Nature Communications·Tianyu ZhuChuanbing Tang
Dec 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Chiara SportelliNicoletta Ditaranto
Oct 19, 2019·IET Nanobiotechnology·Alireza Allafchian, Seyed Sajjad Hosseini
Nov 28, 2018·Advanced Healthcare Materials·Peng YangChuanbing Tang
Dec 12, 2018·Nature Communications·Md Anisur RahmanChuanbing Tang
Nov 17, 2020·International Journal of Biological Macromolecules·Mohammad Taghi KhorasaniMoein Amoupour
Jan 13, 2021·ACS Infectious Diseases·Rashin Namivandi-ZangenehCyrille Boyer

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