Red and NIR light dosimetry in the human deep brain

Physics in Medicine and Biology
A PitzschkeG Wagnières

Abstract

Photobiomodulation (PBM) appears promising to treat the hallmarks of Parkinson's Disease (PD) in cellular or animal models. We measured light propagation in different areas of PD-relevant deep brain tissue during transcranial, transsphenoidal illumination (at 671 and 808 nm) of a cadaver head and modeled optical parameters of human brain tissue using Monte-Carlo simulations. Gray matter, white matter, cerebrospinal fluid, ventricles, thalamus, pons, cerebellum and skull bone were processed into a mesh of the skull (158 × 201 × 211 voxels; voxel side length: 1 mm). Optical parameters were optimized from simulated and measured fluence rate distributions. The estimated μeff for the different tissues was in all cases larger at 671 than at 808 nm, making latter a better choice for light delivery in the deep brain. Absolute values were comparable to those found in the literature or slightly smaller. The effective attenuation in the ventricles was considerably larger than literature values. Optimization yields a new set of optical parameters better reproducing the experimental data. A combination of PBM via the sphenoid sinus and oral cavity could be beneficial. A 20-fold higher efficiency of light delivery to the deep brain was achie...Continue Reading

References

Jul 1, 1995·Computer Methods and Programs in Biomedicine·L WangL Zheng
Apr 1, 1993·Physics in Medicine and Biology·M FirbankD T Delpy
Feb 1, 1996·Physics in Medicine and Biology·B J TrombergY Tadir
Jun 12, 1999·Journal of Photochemistry and Photobiology. B, Biology·T Karu
Jan 4, 2001·Neuroscience Letters·K S McNaught, P Jenner
Jun 3, 2004·Lancet·Ali SamiiBruce R Ransom
Apr 20, 2006·Parkinsonism & Related Disorders·Yasin TemelVeerle Visser-Vandewalle
Mar 9, 2007·Journal of Biomedical Optics·Even Angell-PetersenSteen J Madsen
Nov 13, 2007·Journal of Biomedical Optics·Ying T PanCong W Du
Apr 9, 2008·Nature Medicine·Jeffrey H KordowerC Warren Olanow
Apr 10, 2008·British Medical Bulletin·C A Davie
May 3, 2008·Physics in Medicine and Biology·E Salomatina, A N Yaroslavsky
Jun 16, 2009·Lancet·Andrew J LeesTamas Revesz
Jun 19, 2009·Molecular Neurodegeneration·Patricia A TrimmerUri Oron
Nov 3, 2009·The Journal of Comparative Neurology·Victoria E ShawJohn Mitrofanis
May 14, 2010·Journal of Alzheimer's Disease : JAD·Vanessa A Morais, Bart De Strooper
Dec 21, 2010·Biomedical Optics Express·Qianqian Fang
Mar 18, 2011·Zygote : the Biology of Gametes and Early Embryos·M CroccoM I Mariano
Oct 1, 2011·Lasers in Surgery and Medicine·Sulbha K SharmaMichael R Hamblin
May 12, 2012·Cardiology Research and Practice·Rolf SpirigSidney Shaw
May 24, 2013·Journal of Biomedical Optics·Caigang Zhu, Quan Liu

❮ Previous
Next ❯

Citations

Mar 12, 2016·Lasers in Medical Science·Mohammed A HadisWilliam M Palin
Oct 19, 2016·BBA Clinical·Michael R Hamblin
Jan 13, 2018·Molecular Neurobiology·Farzad SalehpourMichael R Hamblin
Nov 14, 2017·Journal of Neuroscience Research·Michael R Hamblin
Jul 4, 2019·Current Allergy and Asthma Reports·Victoria A WickenheisserTeresa Kathleen Tarrant
Feb 24, 2019·Neurophotonics·Paolo CassanoQianqian Fang
Aug 24, 2019·Photochemistry and Photobiology·Collin T InglutHuang-Chiao Huang
Feb 25, 2021·Lasers in Medical Science·Fatemeh RamezaniMichael R Hamblin
Jun 26, 2021·Journal of Refractive Surgery·George D KymionisGeorges Wagnières
Jul 6, 2021·Aging and Disease·Damir NizamutdinovJason H Huang
Mar 19, 2020·Cerebral Cortex Communications·Grzegorz M DmochowskiJacek P Dmochowski
Jul 30, 2021·Ageing Research Reviews·Fabrízio Dos Santos CardosoSérgio Gomes da Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2021 Meta ULC. All rights reserved