PMID: 26770551Jan 16, 2016Paper

Red blood cell distribution width as a prognostic biomarker for mortality in traumatic brain injury

International Journal of Clinical and Experimental Medicine
Biao Zhang, Jin Zhao

Abstract

Traumatic brain injury (TBI) often cause morbidity and mortality, but it is hard to obtained predictive biomarkers. Red blood cell distribution width (RDW) has been reported as a mortalmarker in cardiovascular disease. But it is unknown whethr RDW is associated with the mortality of TBI patients. The aim of this study is to identify whether RDW is a prognostic biomarker for TBI mortality. A total of 122 patients with TBI were included retrospectively. Patients were divided into Survival Group and Non-survival Group, RDW was compared between 2 groups. Receiver Operating Curve (ROC) was used to evaluate the mortality predictive performances. 122 patients were included, the male-female ratio was 2.59 (88/34) with their median age of 49.5 (17-89) years. 13 (11.93%) of them were divided into Non-survival Group. We observed significant difference in RDW between two groups (P < 0.05). The cut-off level for RDW in TBI was ≥ 12.85, with the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) were 65.4%, 95.7%, 69.7%, 82.6%, respectively; and area under the curve was 0.805 (95% confidence interval [CI]: 0.703-0.906). Red cell distribution width is a predictor of mortality in patients with TBI.

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