PMID: 26321026Sep 1, 2015Paper

Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study

Croatian Medical Journal
Vlatka PerišaJerko Barbić

Abstract

To determine the prognostic value of baseline red blood cell distribution width (RDW) in diffuse large B cell lymphoma (DLBCL) patients. Data from 81 DLBCL patients diagnosed from 2006 to 2013 at the University Hospital Center Osijek, Osijek, Croatia, were reviewed. We evaluated disease outcome, overall survival (OS) and event-free survival (EFS), and demographic, clinical and laboratory factors affecting outcome. Univariate analysis and Cox regression analysis were used. Median age of patients was 64 years, 29 were men (35.8%). Higher RDW levels (%) were found in patients with advanced Ann Arbor clinical stage (14.94±1.82 vs 13.55±1.54, P=0.001) and in those with poor response to therapy (14.94±1.82 vs 13.55±1.54, P=0.001). Patients with RDW>15% (cut-off was calculated by receiver operating characteristics) had significantly worse OS (median [range], 33 months [20-46] vs 74 months [65-82], P<0.001) and EFS (27 months [15-40] vs 68 months [59-77], P<0.001). Cox regression analysis showed that RDW>15% was an independent prognostic factor for OS (HR 3.654, 95% CI 1.128-11.836) and EFS (HR 2.611, 95% CI 1.012-6-739). High baseline RDW is an independent prognostic marker of poor outcome in patients with DLBCL. RDW could be an easil...Continue Reading

Citations

Mar 7, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Qing-Yong YangYan-Song Guo
Sep 7, 2017·International Journal of Laboratory Hematology·K NishimuraT Eto
Aug 23, 2017·Cancer Biomarkers : Section a of Disease Markers·Jing WangHongfeng Guo
Jun 27, 2019·International Journal of Hematology·Takao YogoKenshi Suzuki
Jan 28, 2021·Analytical Chemistry·Tienan GaoLanqun Mao
Nov 20, 2020·Leukemia Research·Kosuke ObamaHirosaka Inoue

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