Red blood cell distribution width levels correlate with liver fibrosis and inflammation: a noninvasive serum marker panel to predict the severity of fibrosis and inflammation in patients with hepatitis B

Medicine
Wen-Shen XuJing Chen

Abstract

We aimed to study whether red blood cell distribution width (RDW) could be one of the variables determining the extent of liver fibrosis and inflammation in patients with biopsy-proven hepatitis B. A total of 446 hepatitis B virus-infected patients who underwent liver biopsy were divided into 2 groups: absent or mild and moderate-severe according to the severity of liver fibrosis and inflammation. The independent variables that determine the severity of liver fibrosis and inflammation were explored. RDW values increased with progressive liver fibrosis and inflammation. After adjustments for other potent predictors, liver fibrosis (moderate-severe) was independently associated with RDW, platelet, and albumin (odds ratio = 1.121, 0.987, and 0.941, respectively), whereas increased odds ratios of significant inflammation were found for RDW, alanine aminotransferase, albumin, and PLT (odds ratio = 1.146, 1.003, 0.927, and 0.990, respectively). The sensitivity and specificity of model A were 70.0% and 62.9% for detection of significant liver fibrosis [area under the receiver-operating characteristic curve (AUC) = 0.713, P < 0.001]. The sensitivity and specificity of model B were 66.1% and 79.4% for predicting advanced liver inflammat...Continue Reading

References

Feb 15, 2003·Journal of Hepatology·Thierry PoynardUNKNOWN PANFIBROSIS Group
Dec 12, 2003·World Journal of Gastroenterology : WJG·Lun-Gen LuXia-Qiu Zhou
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Alan J DeAngeloDaniel R Ouellette
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·A M ElsharkawyD A Mann
Oct 13, 2006·The American Journal of Gastroenterology·Mehdi MohamadnejadReza Malekzadeh
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna WieckowskaAriel E Feldstein
Jan 4, 2008·Circulation·Marcello TonelliUNKNOWN for the Cholesterol and Recurrent Events (CARE) Trial Investigators
May 13, 2008·Gastroenterology·Scott L Friedman
Jul 12, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Giuseppe LippiGian Cesare Guidi
Nov 18, 2008·Journal of Hepatology·Shruti H MehtaDavid L Thomas
Apr 28, 2009·Archives of Pathology & Laboratory Medicine·Giuseppe LippiGian Cesare Guidi
Aug 12, 2009·Hepatology International·Yun-Fan LiawUNKNOWN Chronic Hepatitis B Guideline Working Party of the Asian-Pacific Association for the Study of the Liver
Aug 12, 2009·Hepatology International·Gamal ShihaUNKNOWN Jury of the APASL Consensus Development Meeting 29 January 2008 on Liver Fibrosis With Without Hepatitis B or C
Jan 16, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Beom Kyung KimKwang Hyub Han
Mar 26, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Richard D SembaLinda P Fried
Aug 28, 2010·Journal of Gastroenterology and Hepatology·Kun ZhouLun-Gen Lu
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Jing ChenQishui Ou
Jan 15, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Zhide HuAnmei Deng
Jan 18, 2013·European Journal of Gastroenterology & Hepatology·Bahadir CeylanEsra Paşaoğlu
Aug 10, 2013·The American Journal of the Medical Sciences·Yalcin SolakAbdulgaffar Vural
Aug 21, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhi-De HuAn-Mei Deng
Oct 18, 2013·Clinical and Molecular Hepatology·Hwa Mok KimWon Seok Choi
Nov 22, 2013·World Journal of Gastroenterology : WJG·Mustafa CengizSeren Ozenirler
Dec 24, 2013·International Journal of Cardiology·Tong LiuGuangping Li
Mar 15, 2014·World Journal of Gastroenterology : WJG·Albert J Czaja
Apr 3, 2014·Hepatitis Monthly·Simin Dokht ShoaeiEsmail Riahi
Apr 12, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Rui HuangChao Wu

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Citations

Aug 28, 2016·The Journal of Surgical Research·Er-Lei ZhangZhi-Yong Huang
Mar 23, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Weichen ZhouJie Liu
Mar 14, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Xihui JiangChao Sun
Jan 18, 2017·Veterinary World·Zaven KaralyanElena Karalova
Jan 17, 2017·Gastroenterology Research and Practice·Qitian HeZhifu Wei
Aug 9, 2017·World Journal of Gastroenterology : WJG·Hemant GoyalElizabeth May
Jan 22, 2019·Scandinavian Journal of Gastroenterology·Ding YuyunLiu Hongmei
Feb 21, 2019·International Journal of Clinical Oncology·Yakup BozkayaFatih Gürler
Aug 23, 2016·World Journal of Gastroenterology : WJG·Da-Wu ZengYue-Yong Zhu
Jul 10, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Linxi ShiNing Li

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Methods Mentioned

BETA
biopsy
PCR
biopsies

Software Mentioned

SPSS

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