Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application

Acta Pharmaceutica Sinica. B
Qing XiaNianping Feng

Abstract

Erythrocytes (red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems (DDS) because of their features of biocompatibility, biodegradability, and long circulating half-life. Accordingly, a "camouflage" comprised of erythrocyte membranes renders nanoparticles as a platform that combines the advantages of native erythrocyte membranes with those of nanomaterials. Following injection into the blood of animal models, the coated nanoparticles imitate RBCs and interact with the surroundings to achieve long-term circulation. In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications. Finally, further functional modifications of the erythrocyte membranes and attempts to fuse the surface properties of multiple cell membranes are discussed, providing a foundation to stimulate extensive research into multifunctional nano-biomimetic systems.

Citations

Oct 17, 2019·Pharmaceutics·Veena VijayanIn-Kyu Park
Nov 27, 2019·Cancers·Jenna C HarrisEmily S Day
Jan 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sheng WangLiangzhu Feng
Mar 22, 2020·Pharmaceutics·Larisa KolevaElena Sinauridze
Apr 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro Baeza
Jun 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuzhen LiXin Ding
Sep 5, 2020·Pharmaceutics·Shi Su, Peter M Kang
Apr 21, 2020·Frontiers in Bioengineering and Biotechnology·Riccardo RampadoMarco Agostini
Aug 23, 2020·Nutrients·Paolino NinfaliEmanuele Salvatore Scarpa
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Ruichen ZhaoXin Zhang
Oct 25, 2020·Pharmaceutics·Nkiruka IbeanuSahar Awwad
Dec 3, 2020·Biosensors & Bioelectronics·Ruixue ZhuIgor Meglinski
Dec 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adrija JhaSrinivas Mutalik
Jan 20, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lingxiao ZhangDaishun Ling
Feb 13, 2021·Small·Fatemeh OroojalianMohammad-Ali Shahbazi
Dec 31, 2020·International Journal of Molecular Sciences·Kiruphagaran ThangarajuPaul W Buehler
Nov 1, 2020·International Journal of Molecular Sciences·Parinaz SabourianAshok Kakkar
Nov 22, 2020·Biology·Carla Jiménez-JiménezMaría Vallet-Regí
Dec 29, 2020·Drug Design, Development and Therapy·Meilin ZhangBaoan Chen
Feb 27, 2021·Clinical and Translational Medicine·Minghai ZhangYu Wang
Sep 19, 2020·Advanced Drug Delivery Reviews·Flávia CastroBruno Sarmento
Jun 17, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Md Abdus Subhan, V P Torchilin
Mar 17, 2021·European Journal of Pharmacology·Nur Najihah Izzati Mat RaniMohd Cairul Iqbal Mohd Amin
Sep 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pratigyan DashMamoni Dash
Mar 30, 2021·Bioactive Materials·Pallabita ChowdhuryMurali M Yallapu
May 5, 2021·Expert Opinion on Drug Delivery·Miguel Pereira-SilvaAna Cláudia Paiva-Santos
Apr 18, 2021·Journal of Biomaterials Science. Polymer Edition·Xingyue DengFei Liang
Jun 3, 2021·International Journal of Molecular Sciences·Giulia Della Pelle, Nina Kostevšek
May 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zahid HussainMohammed A S Abourehab
Jun 3, 2021·Biomolecules·Taylor HanleyBahman Anvari
Jun 19, 2021·Drug Delivery·Yong-Jiang LiDa-Xiong Xiang
Jun 18, 2021·Nano-micro Letters·Shruti Rawal, Mayur Patel
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chaojie ZhuQiwen Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
chip
chips
dynamic light scattering
electron microscopy
electrophoresis
nanoprecipitation
xenograft
fluorescence imaging

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bioconjugate Chemistry
Xiao HanZhuang Liu
Journal of Controlled Release : Official Journal of the Controlled Release Society
Brian T Luk, Liangfang Zhang
Proceedings of the National Academy of Sciences of the United States of America
Che-Ming Jack HuLiangfang Zhang
© 2021 Meta ULC. All rights reserved