Red blood cell membrane concentration of cis-palmitoleic and cis-vaccenic acids and risk of coronary heart disease.

The American Journal of Cardiology
Luc DjousséJohn M Gaziano

Abstract

Although previous studies have suggested associations between plasma palmitoleic acid and coronary heart disease (CHD) risk factors, including blood pressure, inflammation, and insulin resistance, little is known about the relation of palmitoleic acid and CHD. This ancillary study of the Physicians' Health Study was designed to examine whether red blood cell (RBC) membrane cis-palmitoleic acid and cis-vaccenic acid-2 fatty acids that can be synthesized endogenously-are associated with CHD risk. We used a risk set sampling method to prospectively select 1,000 incident CHD events and 1,000 matched controls. RBC membrane fatty acids were measured using gas chromatography. The CHD cases were ascertained using an annual follow-up questionnaire and validated by an End Point Committee through a review of the medical records. In a conditional logistic regression analysis adjusting for demographics, anthropometric, lifestyle factors, and co-morbidity, the odds ratios and 95% confidence intervals (CIs) for CHD were 1.0 (referent), 1.29 (95% CI 0.95 to 1.75), 1.08 (95% CI 0.78 to 1.51), 1.25 (95% CI 0.90 to 1.75), and 1.48 (95% CI 1.03 to 2.14) across consecutive quintiles of RBC membrane cis-palmitoleic acid (p for trend = 0.041). The od...Continue Reading

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Citations

Oct 16, 2012·Circulation. Heart Failure·Luc DjousséJ Michael Gaziano
Jun 25, 2013·American Journal of Medical Genetics. Part a·Kenneth Lyons JonesChristina D Chambers
Jul 25, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Luc DjousséJ Michael Gaziano
Dec 3, 2016·Biological & Pharmaceutical Bulletin·Kohei KawabataYoichi Kawashima
Aug 14, 2018·Molecular Nutrition & Food Research·Camila Oliveira de SouzaPhilip C Calder
Oct 25, 2013·The American Journal of Clinical Nutrition·Yuvaraj MahendranMarkku Laakso
Aug 18, 2020·European Journal of Clinical Nutrition·Liang SunXu Lin
Jul 5, 2013·The American Journal of Clinical Nutrition·Chisa MatsumotoLuc Djoussé
Feb 2, 2021·BMJ Nutrition, Prevention & Health·Lucia AronicaDominic P D'agostino
Jun 21, 2020·Journal of the American College of Cardiology·Arne AstrupRonald M Krauss
Feb 7, 2021·Cancer Research·Margaret M CenteneraLisa M Butler
May 1, 2021·International Journal of Molecular Sciences·Maria NotarnicolaCaterina Messa
Jul 14, 2021·Nature Reviews. Cardiology·Nathalie A ReillyJ Wouter Jukema

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