Red blood cell membrane fluidity in the etiology of multiple sclerosis.

The Journal of Membrane Biology
Gloudina M HonTandi Matsha

Abstract

Organisms adjust the order, or fluidity, of their cellular membranes in response to changes in their physiochemical environment by adjusting the lipid composition of their membranes. We investigated membrane fluidity using the phospholipid, fatty acid and cholesterol content of red blood cells (RBCs) from multiple sclerosis (MS) patients and correlated this with C-reactive protein (CRP) as well as with the severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale (EDSS) and its Functional System Scores. The study group consisted of 31 patients with MS and 30 healthy control subjects. Phospholipids were determined using a colorimetric assay, fatty acids by gas chromatography, cholesterol by an enzymatic assay and CRP by a Beckman nephelometer. Cell membrane fluidity was calculated according to previously established formulae. RBC membrane fluidity as measured by the saturated to polyunsaturated fatty acid ratio was higher in patients than in controls (P = 0.04). The phosphatidylethanolamine saturated to polyunsaturated fatty acid ratio showed highly significant positive correlations with the EDSS and CRP < 5 microg/ml. CRP showed significant inverse correlations with the saturated nature but po...Continue Reading

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Citations

Jul 25, 2015·BMC Neuroscience·Daniele VergaraAnna M Giudetti
May 29, 2016·Metabolic Brain Disease·Meric A AltinozSinan Guloksuz
May 8, 2020·Multiple Sclerosis and Related Disorders·Martin HeineWayne Derman

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