Red blood cell storage time and transfusion: current practice, concerns and future perspectives

Blood Transfusion = Trasfusione Del Sangue
María García-RoaLaura Gutiérrez

Abstract

Red blood cells (RBCs) units are the most requested transfusion product worldwide. Indications for transfusion include symptomatic anaemia, acute sickle cell crisis, and acute blood loss of more than 30% of the blood volume, with the aim of restoring tissue oxygen delivery. However, stored RBCs from donors are not a qualitative equal product, and, in many ways, this is a matter of concern in the transfusion practice. Besides donor-to-donor variation, the storage time influences the RBC unit at the qualitative level, as RBCs age in the storage bag and are exposed to the so-called storage lesion. Several studies have shown that the storage lesion leads to post-transfusion enhanced clearance, plasma transferrin saturation, nitric oxide scavenging and/or immunomodulation with potential unwanted transfusion-related clinical outcomes, such as acute lung injury or higher mortality rate. While, to date, several studies have claimed the risk or deleterious effects of "old" vs "young" RBC transfusion regimes, it is still a matter of debate, and consideration should be taken of the clinical context. Transfusion-dependent patients may benefit from transfusion with "young" RBC units, as it assures longer inter-transfusion periods, while tra...Continue Reading

Citations

Feb 10, 2019·Scientific Reports·Achini K VidanapathiranaPeter J Psaltis
Mar 4, 2021·Journal of Blood Medicine·Nelly Al AudhahLoeki Enggar Fitri
May 1, 2021·International Journal of Molecular Sciences·Narges HadjesfandiariDana V Devine
Jul 4, 2019·Biomacromolecules·Trisha L BaileyMatthew I Gibson

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