Red Blood Cell Transfusion and Surgical Site Infection After Colon Resection Surgery: A Cohort Study

Anesthesia and Analgesia
Michael MazzeffiSamuel Galvagno

Abstract

Surgical site infections (SSIs) after colon surgery remain a critical safety issue. Patients with an SSI have an increased risk of death, prolonged hospitalization, and increased costs of care. Red blood cell (RBC) transfusion is given during the perioperative period to increase blood oxygen delivery, but it is associated with complications, including infection. We hypothesized that RBC transfusion would be associated with increased SSI risk in patients undergoing colon resection surgery. A retrospective cohort study was performed using the 2014 National Surgical Quality Improvement Program participant use file. Patients who had colon resection surgery were identified using current procedural terminology codes. The association between perioperative RBC transfusion and superficial and deep incisional SSIs, organ space SSIs, and postoperative septic shock was modeled using logistic regression with propensity score analysis. Of 23,388 patients who had colon resection surgery, 1845 (7.9%) received perioperative RBC transfusion. After controlling for confounders with propensity score analysis and inverse probability of treatment weighting, RBC transfusion had no apparent association with superficial incisional SSI (odds ratio [OR], ...Continue Reading

References

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Citations

Sep 19, 2017·Anesthesia and Analgesia·Naveen Nathan
Sep 19, 2017·Anesthesia and Analgesia·Aryeh ShanderSteven Brower
Jun 19, 2019·Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality·Dinesh J KurianSolomon Aronson
Nov 28, 2019·AORN Journal·Camila Cristina MantoaniRenata Cristina de Campos Pereira Silveira
Jan 7, 2019·World Journal of Surgical Oncology·Qian-Yun PangHong-Liang Liu
Jun 27, 2019·World Journal of Gastroenterology : WJG·Shan-Ping YeJun Shi
Aug 28, 2020·Anesthesia and Analgesia·Yuchen YuanYuguang Huang
Oct 21, 2020·Anesthesia and Analgesia·Yuchen YuanYuguang Huang
Dec 29, 2020·British Journal of Anaesthesia·Jeremy MeyerRichard J Davies
Nov 18, 2018·British Journal of Anaesthesia·A J FowlerUNKNOWN International Surgical Outcomes Study Group

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