Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trial

Annals of Surgery
Justine RouettePALISI Network

Abstract

The optimal transfusion threshold after surgery in children is unknown. We analyzed the general surgery subgroup of the TRIPICU (Transfusion Requirements in Pediatric Intensive Care Units) study to determine the impact of a restrictive versus a liberal transfusion strategy on new or progressive multiple organ dysfunction syndrome (MODS). The TRIPICU study, a prospective randomized controlled trial conducted in 17 centers, enrolled a total of 648 critically ill children with a hemoglobin equal to or below 9.5 g/dL within 7 days of pediatric intensive care unit (PICU) admission to receive prestorage leukocyte-reduced red-cell transfusion if their hemoglobin dropped below either 7.0 g/dL (restrictive) or 9.5 g/dL (liberal). A subgroup of 124 postoperative patients (60 randomized to restrictive and 64 to the liberal group) were analyzed. This study was registered at http://www.controlled-trials.com and carries the following ID ISRCTN37246456. Participants in the restrictive and liberal groups were similar at randomization in age (restrictive vs. liberal: 53.5 +/- 51.8 vs. 73.7 +/- 61.8 months), severity of illness (pediatric risk of mortality [PRISM] score: 3.5 +/- 4.0 vs. 4.4 +/- 4.0), MODS (35% vs. 29%), need for mechanical venti...Continue Reading

References

Jan 1, 1992·Annals of Internal Medicine·A D Oxman, G H Guyatt
Apr 1, 1989·The American Review of Respiratory Disease
Nov 1, 1988·Critical Care Medicine·M M PollackP R Getson
Jun 5, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Caroline LaverdièreUNKNOWN Canadian Critical Care Trials Group
Feb 27, 2004·British Journal of Haematology·Brenda E S GibsonG Turner
May 12, 2004·Critical Care Clinics·Lena M Napolitano, Howard L Corwin
Apr 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Allan DoctorBenjamin Gaston
Jul 1, 2006·Anesthesiology·UNKNOWN American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies
Nov 2, 2006·Transfusion·France GauvinHeather Hume
Apr 20, 2007·The New England Journal of Medicine·Jacques LacroixUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators Network
Sep 7, 2007·Blood Reviews·Eleftherios C Vamvakas, Morris A Blajchman
Sep 8, 2007·Clinics·Ludhmila Abrahão HajjarFilomena Galas
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Elliott Bennett-GuerreroTimothy J McMahon
Nov 23, 2007·The New England Journal of Medicine·Rui WangJeffrey M Drazen
Jan 2, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alan T TinmouthRobert A Fowler
Apr 19, 2008·American Journal of Respiratory and Critical Care Medicine·Scot T BatemanUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators Network

❮ Previous
Next ❯

Citations

Jun 8, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert I Parker
Jan 7, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Baruch ToledanoJacques Lacroix
Nov 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Oliver KaramUNKNOWN PALISI Network
Nov 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Judith van der WalMartin C J Kneyber
Apr 19, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cornelius T Tyrrell, Scot T Bateman
Aug 17, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Paul A StrickerJohn J McCloskey
Feb 1, 2014·Journal of the American Veterinary Medical Association·Marie K HolowaychukGabrielle Monteith
Dec 18, 2013·The Journal of Thoracic and Cardiovascular Surgery·Michael J WolfWilliam T Mahle
Jan 21, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·E Carreras-GonzalezUNKNOWN Equipo de transporte
Jul 24, 2012·Seminars in Perinatology·Jacques LacroixMarisa Tucci
Jan 9, 2016·Journal of Intensive Care·Surender RajasekaranNabil Hassan
Aug 20, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Richard T FiserHoward L Corwin
Feb 7, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Felix NeunhoefferJörg Michel
Mar 9, 2018·Critical Care Medicine·Jennifer A MuszynskiUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Feb 11, 2014·The Cochrane Database of Systematic Reviews·Kirstin L WilkinsonMichael F Murphy
Aug 31, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Allan DoctorUNKNOWN Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PAL
Aug 31, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jennifer A MuszynskiUNKNOWN Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PA
Aug 31, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Oliver KaramUNKNOWN Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PAL
Sep 5, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Stacey L ValentineUNKNOWN Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PAL
Dec 16, 2010·Paediatric Anaesthesia·Josée Lavoie
Dec 16, 2010·Paediatric Anaesthesia·Jerrold Lerman
Sep 10, 2013·Intensive Care Medicine·Geneviève Du Pont-Thibodeau, Jacques Lacroix
May 21, 2011·Paediatric Anaesthesia·Paul A StrickerLynne G Maxwell
Apr 17, 2012·Paediatric Anaesthesia·Tarun BhallaJoseph D Tobias
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Feb 19, 2014·Critical Care Medicine·Robert I Parker
Jun 4, 2019·Current Opinion in Anaesthesiology·Hua FengLingzhong Meng
Oct 4, 2016·Transfusion·Jennifer A MuszynskiUNKNOWN Pediatric Critical Care Blood Research Network (Blood Net)
Mar 11, 2016·Critical Care Medicine·Peter F LyuDavid J Murphy
Jul 2, 2019·The Journal of Craniofacial Surgery·Wallis T MuhlyPaul A Stricker
Mar 26, 2014·The Journal of Trauma and Acute Care Surgery·Shannon N AckerDenis D Bensard
May 23, 2013·Acta Anaesthesiologica Scandinavica·E L SecherA Afshari
Apr 16, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Geneviève Du Pont-ThibodeauJacques Lacroix
Apr 19, 2015·Current Opinion in Pediatrics·Jacques LacroixGeneviève Du Pont-Thibodeau
Nov 20, 2016·British Journal of Haematology·Helen V NewUNKNOWN British Committee for Standards in Haematology
Apr 12, 2018·Revista da Associação Médica Brasileira·João Carlos Pina FariaRoseli Oselka Saccardo Sarni
Feb 7, 2013·Paediatric Anaesthesia·Edoardo PicettiMaria Luisa Caspani
Sep 8, 2020·ANZ Journal of Surgery·Matthias Z H LuGemma Crighton
May 11, 2021·Frontiers in Pediatrics·Gemma Louise Crighton, Elise J Huisman
Feb 29, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Hong ZhouChunbao Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Care Medicine
Ariane WillemsPediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
The New England Journal of Medicine
Jacques LacroixPediatric Acute Lung Injury and Sepsis Investigators Network
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Jill M CholetteNorma B Lerner
JAMA : the Journal of the American Medical Association
Jean Louis VincentABC (Anemia and Blood Transfusion in Critical Care) Investigators
© 2021 Meta ULC. All rights reserved