PMID: 2443168Sep 18, 1987

Red blood cells Ca2+ pump is not altered in essential hypertension of humans and Kyoto rats

Biochimica Et Biophysica Acta
G DagherA Khefif

Abstract

The kinetic parameters of the Ca2+ pump were assessed in red blood cells of essential hypertensive subjects as compared to their respective controls. Uphill Ca2+ efflux was investigated in Ca2+ -saturated intact red blood cells using a new method recently developed for human red cells (Dagher,G. and Lew, V. J. Physiol. (London), in the press). 45Ca-equilibrated cells were obtained using ionophore A23187 and Ca2+ efflux was assessed after addition of excess CoCl2 which totally inhibits Ca2+ influx and thus exposes uphill Ca2+ extrusion by the pump. The results comprise methodological aspects of the use of this technique in rat red blood cells. The determination of the maximal velocity and the Ca2+ concentration for half-maximal stimulation (KCa 0.5) did not reveal any alteration in essential hypertensives and spontaneously hypertensive rats as compared to their controls.

References

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Citations

Nov 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·N V Maksimova, V V Petrov
Jun 1, 1994·Journal of Pharmacological and Toxicological Methods·G R MonteithB D Roufogalis
Jun 1, 1995·European Journal of Clinical Investigation·N EscobalesL Haddock
Jan 1, 1993·Clinical and Experimental Hypertension : CHE·C SpiekerW Zidek
May 15, 2001·American Journal of Physiology. Cell Physiology·J E RaftosT Tiffert

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