Red cell acid phosphatase: another polymorphism correlated with Malaria?

American Journal of Physical Anthropology
R PalmarinoE Bottini

Abstract

The frequency of PC allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and GdMed prevalence. The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying PA allele for acid phosphatase. The data suggest that the gradient for malaria morbidity directly or indirectly, through interactions with thalassemia and G6PD polymorphisms, mediated by the habit of eating Vecia faba, may have had a significant role in determining the heterogeneous distribution of acid phosphatase polymorphism in Sardinia. Besides malaria, other environmental factors related with altitude seem to have been very important in shaping the present pattern of distribution of both acid phosphatase and G6PD polymorphisms in Sardinia.

References

Sep 1, 1975·American Journal of Physical Anthropology·P L WorkmanE Bottini
Jul 1, 1973·Annals of Human Genetics·D M SwallowH Harris
Jan 29, 1971·Science·E BottiniG Antognoni
Jul 7, 1962·Nature·K S WARREN
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Citations

Sep 1, 1976·American Journal of Physical Anthropology·P LucarelliE Bottini
Apr 1, 1994·American Journal of Physical Anthropology·P MoralG Vona
Oct 1, 1978·Journal of Medical Genetics·E BottiniG Maggioni
Sep 2, 2010·The American Journal of the Medical Sciences·Fulvia Gloria-BottiniEgidio Bottini
Jun 27, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Fulvia Gloria-BottiniEgidio Bottini
Dec 19, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·E BottiniN Bottini
Jun 1, 1983·American Journal of Physical Anthropology·D TillsI Economidou
Dec 1, 1981·American Journal of Physical Anthropology·W S Pollitzer
Jan 1, 1992·Hemoglobin·B Masala
Oct 2, 2012·Indian Journal of Clinical Biochemistry : IJCB·Benedicta D'SouzaVivian D'Souza
May 23, 2019·BMC Medical Genetics·Zhuo YangBing Han

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