Red cell and platelet transfusion burden following myeloablative allogeneic haemopoietic stem cell transplantation

Internal Medicine Journal
A Le ViellezDuncan Purtill

Abstract

Adult allogeneic haemopoietic stem cell transplant (HSCT) usually requires blood transfusion support of red cells and platelets. There are few studies describing transfusion burden after allogeneic HSCT. This study aims to quantify and identify determinants of transfusion burden after allogeneic HSCT to improve planning, inventory management and patient counselling. A retrospective audit of blood use (red cells and platelets) of all adult HSCT (n = 169) was performed over an 8-year period extracted from pathology and hospital databases. ABO compatibility, graft type, conditioning regimens and patient factors were analysed for up to 12 months post transplant. Transfusion burden was lower than expected and lower than reported by other groups. The median number of units transfused was four red cells and four platelets by day 30, and six red cells and six platelets by day 365. The median time to transfusion independence was 12 days for red cells and 16 days for platelets. Factors associated with increased red cell use included sex, disease stage, graft type (cord blood) and ABO compatibility. Disease stage and graft type (cord blood) were associated with increased platelet transfusion. Donor and patient characteristics are associat...Continue Reading

References

Nov 10, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea BacigalupoMary Horowitz
Dec 20, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Navneet S MajhailUNKNOWN Sociedade Brasileira de Transplante de Medula Ossea (SBTMO)
Mar 27, 2012·Hematology/oncology and Stem Cell Therapy·N S MajhailUNKNOWN Sociedade Brasileira de Transplante de Medula Ossea (SBTMO)
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Navneet Singh MajhailAndre Tichelli
Dec 12, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nancy RobitailleMichel Duval
May 10, 2013·The New England Journal of Medicine·Simon J StanworthUNKNOWN TOPPS Investigators

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Citations

Nov 5, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rahul NaithaniManoj Singh
Feb 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jason TayDean Fergusson

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