Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults.

Neurobiology of Aging
May A BeydounShari R Waldstein

Abstract

Anemia (blood hemoglobin [Hb] <13 g/dL among males; <12 g/dL among females) and elevated red cell distribution width (RDW) are potential risk factors for reduced brain white matter integrity (WMI), reflected by lower fractional anisotropy or increased mean diffusivity. Cross-sectional data with exposure-outcome lag time was used, whereby hematological exposures (RDW and Hb) and covariates were compiled from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with available visit 1 (v1; 2004-2009) and/or v2 (2009-2013) data; while diffusion tensor magnetic resonance imaging (dMRI) outcome data were collected at HANDLS SCAN visit (vscan: 2011-2015, n = 214, mean follow-up from v1 ±SD: 5.6 ± 1.8 year). Multivariable-adjusted linear regression analyses were conducted, overall, stratifying by sex, and further restricting to the nonanemic for RDW exposures in part of the analyses. Among males, RDW(v1) was linked with lower global mean fractional anisotropy (standardized effect size b = -0.30, p= 0.003, q < 0.05; basic model), an association only slightly attenuated with further covariate adjustment. Anemia was not a risk factor for poor WMI, independently of RDW. Ultimately, pending further longitudina...Continue Reading

References

Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Jul 6, 2005·Archives of General Psychiatry·Philip R SzeszkoKelvin O Lim
Jun 5, 2007·Biological Psychiatry·Kelly P CosgroveJulie K Staley
Mar 12, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M A BeydounY Wang
Jul 19, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Derek K Jones
Mar 25, 2009·Archives of Internal Medicine·Todd S PerlsteinJoshua A Beckman
Nov 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kushang V PatelJack M Guralnik
Nov 4, 2011·Nature Reviews. Neuroscience·Berislav V Zlokovic
Jan 31, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Johannes J M L Hoffmann
Jun 8, 2012·Journal of Alzheimer's Disease : JAD·Enrica CavedoGiovanni B Frisoni
Aug 11, 2012·Advances in Experimental Medicine and Biology·Kushang V PatelJoseph M Rifkind
Oct 30, 2012·Archives of Gerontology and Geriatrics·Zeynel Abidin ÖztürkYalçın Kepekçi
Jun 12, 2013·Alzheimer Disease and Associated Disorders·Jennifer WeuveDenis A Evans
Jan 15, 2014·Molecular Psychiatry·N G FauxA I Bush
May 16, 2014·Journal of the American Geriatrics Society·Charles R JonassaintMichelle C Carlson
Aug 16, 2014·Journal of the Neurological Sciences·Shiu-Dong ChungJiunn-Horng Kang
Feb 25, 2015·BioMed Research International·Ioana Mozos
Sep 13, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea L C SchneiderRebecca F Gottesman
Nov 26, 2015·Journal of Alzheimer's Disease : JAD·Martha DlugajUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Jan 19, 2016·Rejuvenation Research·Caterina TrevisanGiuseppe Sergi
Mar 15, 2018·Ciência & saúde coletiva·Natane Daiana Silva SousaAdriana de Azevedo Paiva
Sep 12, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·May A BeydounAlan B Zonderman
May 29, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Emine Dagistan, Zeliha Cosgun
Jun 18, 2019·Alzheimer Disease and Associated Disorders·Stefan WalterM Maria Glymour
Jun 28, 2019·Frontiers in Human Neuroscience·Danielle ShakedShari R Waldstein
Jul 18, 2019·Dementia and Geriatric Cognitive Disorders·Yu TaniguchiShoji Shinkai
Mar 19, 2020·Current Alzheimer Research·Chien-Tai HongLi-Nien Chien
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Theresa MüllerErika J Laukka

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