Red cell distribution width is associated with endothelial progenitor cell depletion and vascular-related mediators in rheumatoid arthritis

Atherosclerosis
Javier Rodríguez-CarrioAna Suárez

Abstract

The role of Red Cell Distribution Width (RDW) as a predictor of cardiovascular (CV) events has been proposed in a variety of conditions, including Rheumatoid Arthritis (RA). However, the mechanisms underlying this effect are still unknown. Since inflammation and Endothelial Progenitor Cells (EPCs) imbalance have been reported in RA patients to be related to CV disease, we wondered whether RDW could be linked to endothelial repair failure in RA. EPCs (CD34+VEGFR2+CD133+) were quantified by flow cytometry in peripheral blood samples from 194 RA patients. IFNα, TNFα, IFNγ, IL-8, VEGF, GM-CSF, MCP-1, ICAM-1, EGF, Leptin and Resistin serum levels were quantified by immunoassays. Clinical and immunological parameters as well as history of traditional CV risk factors and CV events were registered from medical records. RDW was measured in complete blood cell count analyses. RDW was negatively related to EPC counts in patients with established disease (>1 year, n=125) (r=-0.306, p<0.001). Moreover, RDW was independently associated to an EPC depletion in the whole group (β [95% CI]: -3.537 [-6.162, -0.911], p=0.009) after adjusting for clinical parameters, disease duration, treatments and traditional CV risk factors. Additionally, RDW wa...Continue Reading

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Citations

Aug 19, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Javier Rodríguez-CarrioAna Suárez
Sep 1, 2018·International Journal of Rheumatic Diseases·Gabriel Horta-Baas, María Del Socorro Romero-Figueroa
Jul 4, 2018·BioMed Research International·Suzan Demir PektasOzcan Erel
Apr 4, 2018·Pediatrics in Review·Melissa Kaori Silva Litao, Deepak Kamat
Sep 25, 2018·Chinese Medical Journal·Ling-Bing MengTao Gong
Aug 6, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jie LinJunhui Xia

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