Abstract
The role of Red Cell Distribution Width (RDW) as a predictor of cardiovascular (CV) events has been proposed in a variety of conditions, including Rheumatoid Arthritis (RA). However, the mechanisms underlying this effect are still unknown. Since inflammation and Endothelial Progenitor Cells (EPCs) imbalance have been reported in RA patients to be related to CV disease, we wondered whether RDW could be linked to endothelial repair failure in RA. EPCs (CD34+VEGFR2+CD133+) were quantified by flow cytometry in peripheral blood samples from 194 RA patients. IFNα, TNFα, IFNγ, IL-8, VEGF, GM-CSF, MCP-1, ICAM-1, EGF, Leptin and Resistin serum levels were quantified by immunoassays. Clinical and immunological parameters as well as history of traditional CV risk factors and CV events were registered from medical records. RDW was measured in complete blood cell count analyses. RDW was negatively related to EPC counts in patients with established disease (>1 year, n=125) (r=-0.306, p<0.001). Moreover, RDW was independently associated to an EPC depletion in the whole group (β [95% CI]: -3.537 [-6.162, -0.911], p=0.009) after adjusting for clinical parameters, disease duration, treatments and traditional CV risk factors. Additionally, RDW wa...Continue Reading
References
Sep 6, 2003·Atherosclerosis·Sven HänselJens Passauer
Dec 17, 2003·Circulation·Naveed SattarIain B McInnes
Jan 12, 2005·Circulation·Johannes GrisarJosef S Smolen
Jun 25, 2005·Annals of the Rheumatic Diseases·K HerbrigJ Passauer
Oct 29, 2005·Arthritis and Rheumatism·Inmaculada del RincónAgustín Escalante
Feb 3, 2007·Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Llorca
May 26, 2007·Nature Reviews. Immunology·Iain B McInnes, Georg Schett
Jul 20, 2007·Blood·Michael F DennyMariana J Kaplan
Jan 15, 2008·Seminars in Arthritis and Rheumatism·Athanasios N GeorgiadisAlexandros A Drosos
Aug 7, 2008·Rheumatology·C G EganV Sorrentino
Oct 31, 2008·Current Hypertension Reports·Jarrod D KnudsonJohnathan D Tune
May 13, 2009·Nature Reviews. Rheumatology·Peter E Westerweel, Marianne C Verhaar
Jul 21, 2009·Cardiovascular Research·Stavros ApostolakisDemetrios A Spandidos
Oct 31, 2009·Arthritis and Rheumatism·Jörg H W DistlerOliver Distler
Jan 19, 2010·The Journal of Rheumatology·Kai-Hang YiuHung-Fat Tse
Feb 18, 2010·Arthritis Research & Therapy·Vanina Jodon de VillerochéYannick Allanore
Aug 11, 2010·Rheumatology·Jessica A B van NiesTom W J Huizinga
Oct 20, 2010·Circulation·Maik DrechslerOliver Soehnlein
Feb 26, 2011·Clinical Rheumatology·Ferdinand Breedveld
Mar 23, 2011·Atherosclerosis·Luis Rodríguez-RodríguezMiguel A González-Gay
Aug 9, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jason M LappéJeffrey L Anderson
Aug 17, 2011·Arthritis Research & Therapy·Lena InnalaSolveig Wållberg-Jonsson
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Nov 23, 2011·International Journal of Cardiology·Huseyin UyarelMehmet Ergelen
Mar 20, 2012·Circulation Research·Oliver Soehnlein
May 3, 2012·Arthritis and Rheumatism·Seth G ThackerMariana J Kaplan
Oct 9, 2012·Atherosclerosis·Yaron ArbelShmuel Banai
Aug 10, 2013·The American Journal of the Medical Sciences·Yalcin SolakAbdulgaffar Vural
Aug 21, 2013·The Journal of Rheumatology·Sofia AjeganovaIngiäld Hafström
Aug 21, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhi-De HuAn-Mei Deng
Sep 10, 2013·Journal of cardiology·Ibrahim AkpinarIbrahim Celal Haznedaroglu
Jan 28, 2014·PloS One·Javier Rodríguez-CarrioAna Suárez
Feb 18, 2014·Atherosclerosis·Eric MalaudJeannette Fareh
Jun 11, 2014·Nature Reviews. Rheumatology·Helen L WrightSteven W Edwards
Jun 20, 2014·Rheumatology·Patricia LópezAna Suárez
Jul 12, 2014·Arthritis Research & Therapy·Mercedes García-BermúdezMiguel A González-Gay
Citations
Aug 19, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Javier Rodríguez-CarrioAna Suárez
Apr 24, 2015·Clinical Rheumatology·Sobia HassanStanley Ballou
Jan 28, 2016·Arthritis & Rheumatology·Javier Rodríguez-CarrioAna Suárez
Jul 21, 2016·International Journal of Laboratory Hematology·M KucukN Unal
Aug 23, 2018·Rejuvenation Research·Donatella PozCarmela Rita Balistreri
Sep 1, 2018·International Journal of Rheumatic Diseases·Gabriel Horta-Baas, María Del Socorro Romero-Figueroa
Oct 12, 2018·Postgraduate Medical Journal·Hang QianXinwen Min
Dec 24, 2018·Rejuvenation Research·Carmela Rita BalistreriGiovanni Ruvolo
Jun 2, 2018·Chonnam Medical Journal·Ki Hong LeeNuri Lee
Jul 4, 2018·BioMed Research International·Suzan Demir PektasOzcan Erel
Apr 4, 2018·Pediatrics in Review·Melissa Kaori Silva Litao, Deepak Kamat
Sep 25, 2018·Chinese Medical Journal·Ling-Bing MengTao Gong
Aug 6, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jie LinJunhui Xia
Mar 20, 2019·BMC Rheumatology·Julia HeldGünter Weiss