PMID: 6540538Jul 1, 1984Paper

Red cell flexibility and platelet aggregation in patients with chronic obstructive vascular disease (COAD) and study of therapeutic approaches

Angiology
J L AmbrusR H Moore

Abstract

The red blood cell flexibility was studied in the blood of twenty patients with severe peripheral vascular disease and twenty matched controls. Patients exhibited significantly less red cell flexibility than controls. In both groups there was an inverse relationship between age and red cell flexibility. No correlation was found between red cell flexibility and sex or smoking history. Pentoxifylline, a xanthine derivative which inhibits phosphodiesterases and platelet aggregation, was found to increase red cell flexibility. This effect of the drug was greater on red cells with imparied flexibility than on normal cells. Various prostaglandins by contrast were found to decrease red cell flexibility, this could be compensated for by pentoxifylline. Forty patients with COAD were treated intravenously with PgE1. Significant inhibition of platelet aggregation and clinical improvement was noticed. It is suggested that combinations of PgE1 and pentoxifylline should be explored in clinical studies.

References

Dec 1, 1975·Thrombosis Research·K K WuM B Megan
Jul 1, 1977·Angiology·L Dintenfass
Sep 1, 1976·Journal of Clinical Pathology·H L ReidT L Dormandy

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Citations

Jul 1, 1989·Clinical and Experimental Pharmacology & Physiology·M J SturmR R Taylor
Jun 1, 1993·American Journal of Hematology·M De BuyzereD L Clement
Mar 1, 1990·Chest·F HaasH Pineda
Apr 29, 2009·Pharmacotherapy·Paul P DobeshEmily L Persson
Mar 15, 1990·Thrombosis Research·M MahafzahJ L Ambrus

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