PMID: 41369Sep 15, 1979

Red cell metabolism and function in shock (author's transl)

Wiener medizinische Wochenschrift
K M GoebelH Kaffarnik


In patients with shock the metabolism and O2-function of the erythrocytes were studied following separation according to cell-age by density layer centrifugation using a new supporting medium. Metabolic acidosis in patients with postoperative shock (n=8) and in patients with shock due to severe congestive heart failure (n=12) provoked decreased levels of 2,3-diphosphoglycerate, ADP, ATP and reduced glutathione. Raised lactate/pyruvate ratios were observed also in both groups, whereas the O2-function of the erythrocytes was markedly disturbed in all patients. Patients of both groups received glucocorticoid-infusions resulting in a significant improvement of the extent and pattern of the red cell metabolic disorder.

Related Concepts

Diphosphoglyceric Acids
Erythrocyte Survival
Myocardial Failure
Hydrogen-Ion Concentration
Oxygen Consumption
Shock, Surgical

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