Red cell receptors as access points for malaria infection

Current Opinion in Hematology
Nichole D Salinas, Niraj H Tolia

Abstract

Red cell receptors provide unique entry points for Plasmodium parasites to initiate blood-stage malaria infection. Parasites encode distinct ligands that bind specifically to both highly abundant and low-copy receptors. Recent advances in the understanding of molecular and structural mechanisms of these interactions provide fundamental insights into receptor-ligand biology and molecular targets for intervention. The review focuses on the requirements for known interactions, insight derived from complex structures, and mechanisms of receptor/ligand engagement. Further, novel roles for established red cell membrane proteins, parasite ligands and associated interacting partners have recently been established in red cell invasion. The new knowledge underlines the intricacies involved in invasion by a eukaryotic parasite into a eukaryotic host cell demonstrated by expanded parasite ligand families, redundancy in red cell receptor engagement, multitiered temporal binding, and the breadth of receptors engaged.

References

Aug 5, 1976·The New England Journal of Medicine·L H MillerM H McGinniss
Jul 1, 1994·Molecular and Biochemical Parasitology·W H StaffordA A Holder
Jan 1, 1995·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Y Colin
Jul 1, 1997·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O O Blumenfeld, C H Huang
Jun 21, 2001·Immunological Reviews·M Krych-Goldberg, J P Atkinson
Dec 4, 2002·The Journal of Experimental Medicine·D C Ghislaine MayerLouis H Miller
Apr 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vikas K GoelSteven S Oh
Nov 25, 2003·The Journal of Biological Chemistry·Xuerong LiSteven S Oh
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·D C Ghislaine MayerLouis H Miller
Oct 20, 2007·Experimental and Molecular Pathology·Kathryn T IaconoSandra J Saouaf
Mar 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·D C Ghislaine MayerLouis H Miller
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wai-Hong ThamAlan F Cowman
Jul 12, 2011·Nature Structural & Molecular Biology·Joseph D BatchelorNiraj H Tolia
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christopher L KingPeter A Zimmerman
Nov 21, 2012·PLoS Pathogens·S Josefin BartholdsonGavin J Wright
Jan 22, 2013·Seminars in Cell & Developmental Biology·Bart C JongbloetsR Jeroen Pasterkamp
Jan 15, 2014·PLoS Pathogens·Joseph D BatchelorNiraj H Tolia
Feb 11, 2014·Cellular Microbiology·Brian M Malpede, Niraj H Tolia
Jun 27, 2014·Clinical and Vaccine Immunology : CVI·Francis B NtumngiaJohn H Adams
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·K Sony ReddyDeepak Gaur

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Citations

Aug 23, 2016·Biochemical and Biophysical Research Communications·Mohd Shoeb AlamYagya D Sharma
Nov 13, 2019·Infection and Immunity·Bishwanath Kumar ChourasiaPawan Malhotra
May 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Edwin ChenNiraj Harish Tolia

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