Red clover extract: a putative source for simultaneous treatment of menopausal disorders and the metabolic syndrome

Menopause : the Journal of the North American Menopause Society
Monika Mueller, A Jungbauer

Abstract

Currently, red clover extract is used to treat menopausal disorders as an alternative to classic hormone therapy. Several human and animal studies have attributed hypolipidemic, hypoglycemic, or antiatherosclerotic effects to red clover extract or isoflavones. This study was designed to determine the peroxisome proliferator-activated receptor (PPAR) gamma activation by red clover extract. The PPARgamma binding affinities and the transactivation activities of red clover extracts, isoflavones, and their metabolites were analyzed. The presence of specific substances in the extracts was proved by high-performance liquid chromatography/electrospray ionization/mass spectrometry. The red clover extracts and the compounds genistein and biochanin A were potent PPARgamma ligands and activators. Several metabolites exerted higher binding affinities or transactivational activities than their precursor molecules. 6-Hydroxydaidzein exerted a more than 100-fold higher binding affinity than its precursor daidzein. The maximal transactivational activity of 6-hydroxydaidzein and 3'-hydroxygenistein exceeded even that of rosiglitazone, a known PPARgamma agonist. Equol and O-desmethylangolensin showed an approximately fivefold higher binding affin...Continue Reading

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Citations

Nov 5, 2013·Journal of Agricultural and Food Chemistry·Li ChenYong-Li Du
May 12, 2009·Menopause : the Journal of the North American Menopause Society·Evelyne ReiterAlois Jungbauer
Jan 16, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Alois Jungbauer, Svjetlana Medjakovic
Aug 2, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Evelyne ReiterAlois Jungbauer
Aug 30, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Markus LipovacMartin Imhof
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Aug 2, 2014·Biochemical Pharmacology·Limei WangAtanas G Atanasov
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Sep 18, 2020·Cancers·Giuseppina AugimeriDaniela Bonofiglio
Nov 7, 2019·Nutrients·Li-Ru ChenKuo-Hu Chen
Dec 2, 2020·European Journal of Medicinal Chemistry·Ankur Kumar TanwarVikas Jaitak
Apr 4, 2021·International Journal of Molecular Sciences·Li-Ru Chen, Kuo-Hu Chen
Jul 21, 2021·Chinese Medicine·Xiuzhu LiShengpeng Wang
Nov 27, 2008·Analytical Biochemistry·Monika Mueller, Alois Jungbauer
Aug 15, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Nese YukselMichel Fortier

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