Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer

Intestinal research
Ramish RiazArfa Benish

Abstract

Colorectal cancer has long been considered disease of the West, typically occurring in old age; however, the incidence is rising in Asia. The pattern of disease is quite different in Asia, occurring at a younger age and at an advanced stage. Recognition of disease at an early stage is still a challenge for physicians. Few data are available regarding young-onset colorectal cancer in Pakistan. We conducted this study to fill this gap and provide deeper insight into clinical symptoms and histopathological features of young-onset colorectal cancer. We collected data regarding clinical features by directly interviewing patients and obtaining histopathological data from hospital records. Patients aged less than 50 years were included in the study. Statistical analysis was performed using IBM SPSS version 20.0. Results in 105 patients showed mean age at diagnosis was 35.90±9.39, with male predominance; the majority of patients had no family history of colorectal cancer. Most patients had left-sided tumors with advance stage and intermediate grade (grade 2). Mucinous histology was common. Rectal bleeding was the first symptom for left-sided tumors, whereas most of the right-sided lesions presented with sudden obstruction. Painless rec...Continue Reading

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Citations

Nov 17, 2017·Intestinal research·Yoon Suk Jung
May 31, 2018·The Korean Journal of Internal Medicine·Nam Hee KimYoon Suk Jung
Dec 7, 2018·Molecular Oncology·Gianluca MauriSalvatore Siena
Mar 31, 2019·Cancer Medicine·Feng ZhiqiangZhao DeJian
Feb 4, 2019·Current Treatment Options in Gastroenterology·Anand Venugopal, Elena M Stoffel
Dec 29, 2020·ANZ Journal of Surgery·Ashray RajagopalanWilliam Teoh
Jan 23, 2021·Expert Review of Gastroenterology & Hepatology·Obaida DairiLynn F Butterly

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