Red ginseng extract improves coronary flow reserve and increases absolute numbers of various circulating angiogenic cells in patients with first ST-segment elevation acute myocardial infarction

Phytotherapy Research : PTR
Chul-Min AhnDo-Sun Lim

Abstract

The effects of red ginseng extract on circulating angiogenic cell mobilization and improvement of microvascular integrity were evaluated in ST-elevation acute myocardial infarction (AMI) patients during 8-month follow-up. AMI patients (n = 50) were randomly assigned to the red ginseng group (3 g/day, n = 25) or the placebo group (n = 25) after coronary stenting. Coronary flow reserve (CFR) was measured at baseline and at 8 months with an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34(+) , CXCR4(+) , CD117(+) , CD133(+) and C-met(+) were measured at baseline, 1 day, 5 days and at 8 months. CFR were similar between the two groups at baseline, and CFR was significantly higher in the red ginseng group than in the placebo group (2.80 ± 0.91 and 2.56 ± 0.77, p < 0.05, respectively) after 8 months of red ginseng administration. The absolute numbers of circulating CD34(+) , CXCR4(+) and CD117(+) cells were significantly higher in the red ginseng group at 1 and 5 days after stenting. Significant positive correlations were found between the numbers of circulating angiogenic cells at day 1 and the changes from baseline in CFR for CD34(+) , CXCR4(+) , CD117(+) and C-met(+) ce...Continue Reading

References

Sep 17, 1998·The New England Journal of Medicine·M Angell, J P Kassirer
Nov 20, 1998·JAMA : the Journal of the American Medical Association·D M EisenbergR C Kessler
Mar 8, 2002·Toxicology·Yoo K KimLester Packer
Mar 10, 2004·The New England Journal of Medicine·Christopher P CannonUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators
Aug 13, 2004·The New England Journal of Medicine·Pim van der HarstDirk J van Veldhuisen
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Soon Jun HongChang Gyu Park
Apr 4, 2006·Journal of the American College of Nutrition·John L SievenpiperVladimir Vuksan
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·V SchächingerA M Zeiher
Feb 21, 2007·Basic & Clinical Pharmacology & Toxicology·Yong-Ri JinYeo-Pyo Yun
Nov 2, 2007·European Journal of Clinical Investigation·R G TuranB E Strauer
May 14, 2008·Molecular Medicine·Rinki RayDaniel R Meldrum
Aug 8, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-H HeoM Kim
Aug 30, 2008·British Journal of Clinical Pharmacology·Dai-Ja JangEdzard Ernst

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Citations

Jun 26, 2018·Canadian Journal of Physiology and Pharmacology·Xiaohong Tracey Gan, Morris Karmazyn
Sep 13, 2012·Phytotherapy Research : PTR·Johannah L ShergisCharlie C Xue
Feb 8, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michael SarheneGuanwei Fan

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