Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro
Abstract
Tau, a microtubule-associated protein expressed in mature neurons, interacts with tubulin to promote the assembly and stabilization of microtubules. However, abnormally hyperphosphorylated tau dissociates from microtubules and self-aggregates. Tau aggregates, including paired helical filaments and neurofibrillary tangles, promote neuronal dysfunction and death and are the defining neuropathological feature of tauopathies. Therefore, suppressing tau aggregation or stimulating the dissociation of tau aggregates has been proposed as an effective strategy for treating neurodegenerative diseases associated with tau pathology such as Alzheimer's disease (AD) and frontotemporal dementia. Interestingly, ginsenosides extracted from Panax ginseng reduced the hippocampal and cortical expression of phosphorylated tau in a rat model of AD. However, no studies have been conducted into the effect of red ginseng (RG) and its components on tau pathology. Here, we evaluated the effect of Korean red ginseng extract (KRGE) and its components on the aggregation and disassociation of tau. Using the thioflavin T assay, we monitored the change in fluorescence produced by the aggregation or disassociation of tau K18, an aggregation-prone fragment of ta...Continue Reading
References
Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons
Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322.
Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro
Cardiovascular Diseases and Panax ginseng: A Review on Molecular Mechanisms and Medical Applications
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