Red nodular melanoma of the penile foreskin: A case report and literature review

Molecular and Clinical Oncology
Yuki MaruyamaYasutomo Nasu

Abstract

The penis is an extremely rare primary site for malignant melanomas, and the clinical presentation may vary greatly. We herein present the case of a 71-year-old male patient who presented with a 6-year history of two slow growing, asymptomatic red macules on the penile foreskin. On physical examination, the mobility of the foreskin was good, and there was no metastasis on computed tomography and magnetic resonance imaging. The patient underwent segmental circumcision for treatment and histological diagnosis, and the histological examination revealed a malignant melanoma. As cancer cells were identified at the edge of the tissue specimen and computed tomography-positron emission tomography revealed increased uptake of 18F-fluorodeoxyglucose in the penis, wider resection and a right sentinel lymph node biopsy were performed; both specimens came back negative. Two years after the surgery, there has been no evidence of locoregional recurrence or distant metastases. The aim of this report is to alert physicians to include melanoma in the differential diagnosis of red-pigmented lesions of the penile foreskin.

References

Apr 1, 1988·The Journal of Urology·J C Manivel, E E Fraley
Jul 1, 1988·The Journal of Urology·T J StillwellJ E Woods
Feb 1, 1974·The Journal of Urology·R B Bracken, A C Diokno
Jan 1, 1972·Urologia Internationalis·A Tallerman
Oct 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N J FennK Horgan
Apr 1, 1997·Mayo Clinic Proceedings·R S Rogers, L E Gibson
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M KirkwoodR H Blum
Feb 20, 2004·The New England Journal of Medicine·J Meirion ThomasUNKNOWN Scottish Cancer Therapy Network
Jul 29, 2006·Plastic and Reconstructive Surgery·Christopher L HankinsAnna J Anathhanam
Feb 24, 2007·European Urology·Joost A P LeijteSimon Horenblas
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Jan 29, 2010·Acta Dermato-venereologica·Vincenzo De GiorgiTorello Lotti
Nov 2, 2011·Journal of the American Academy of Dermatology·Ahmedin JemalPhyllis A Wingo
Nov 21, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kimberly L BradyMarc D Brown
Nov 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dale HanStanley P Leong
Nov 12, 2014·World Journal of Surgical Oncology·Yunxiang LiQiang Wei
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Nov 26, 2015·Cancer Treatment and Research·Nour KibbiJennifer Nam Choi
Jan 23, 2016·The Lancet Oncology·Andrew J HayesUNKNOWN Reconstructive and Aesthetic Surgeons, and the Scottish Cancer Therapy Network
Nov 23, 2017·Anais Brasileiros De Dermatologia·Fernanda Teixeira OrtegaBruna Tuma

❮ Previous
Next ❯

Citations

Feb 3, 2021·Journal of Clinical Medicine·Emi DikaMaria Concetta Fargnoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Mary K SamplaskiAdam C Berger
© 2022 Meta ULC. All rights reserved