There has been debate as to whether essential tremor has a central origin and over the possible role of the inferior olivary nucleus in its genesis. We used positron emission tomography with radioactive water (H2(15)O) to detect abnormal patterns of cerebral activity associated with this condition, at rest, without tremor, and on posture when the tremor was present. At rest, cerebellar blood flow was significantly increased bilaterally in the group with essential tremor (30-40%) but no increased olivary activity was evident. Essential tremor during arm extension was associated with further abnormal increases in bilateral cerebellar and abnormal red nuclear activation. Again, no olivary overactivity was evident. Voluntary wrist oscillation in control subjects caused only ipsilateral cerebellar activation. We conclude that essential tremor is associated with abnormal bilateral overactivity of cerebellar and red nuclear connections but found no evidence of intrinsic overactivity of the inferior olivary nucleus, as evidenced by raised blood flow.
A noninvasive positron computed tomography technique using oxygen-15--labeled water for the evaluation of neurobehavioral task batteries
The correlation between tremor characteristics and the predicted volume of effective lesions in stereotaxic nucleus ventralis intermedius thalamotomy
Resetting of tremor by mechanical perturbations: a comparison of essential tremor and parkinsonian tremor
Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging
Modulation of postural wrist tremors by magnetic stimulation of the motor cortex in patients with Parkinson's disease or essential tremor and in normal subjects mimicking tremor
A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections
Botulinum toxin restores presynaptic inhibition of group Ia afferents in patients with essential tremor
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Community-based data on associations of disease duration and age with severity of essential tremor: implications for disease pathophysiology
Coherence between low-frequency activation of the motor cortex and tremor in patients with essential tremor
Metabolic abnormality in the cerebellum in patients with essential tremor: a proton magnetic resonance spectroscopic imaging study
Association between essential tremor and other neurodegenerative diseases: what is the epidemiological evidence?
Thalamic connectivity in patients with essential tremor treated with MR imaging-guided focused ultrasound: in vivo fiber tracking by using diffusion-tensor MR imaging
Benefits and risks of pharmacological and surgical treatments for essential tremor: disease mechanisms and current management
Functional correlates of the therapeutic and adverse effects evoked by thalamic stimulation for essential tremor
Klinefelter syndrome has increased brain responses to auditory stimuli and motor output, but not to visual stimuli or Stroop adaptation
Optimum design and sequential treatment allocation in an experiment in deep brain stimulation with sets of treatment combinations
Cerebellar metabolic symmetry in essential tremor studied with 1H magnetic resonance spectroscopic imaging: implications for disease pathology
White matter measures correlate with essential tremor severity-A pilot diffusion tensor imaging study
Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits
Brain positron emission tomography with 2-18 F-2-deoxi-D-glucose of patients with dystonia and essential tremor detects differences between these disorders
Exacerbation of postural tremor with emergence of parkinsonism after treatment with neuroleptic drugs
Differences in neuronal firing rates in pallidal and cerebellar receiving areas of thalamus in patients with Parkinson's disease, essential tremor, and pain
Interaction between blood lead concentration and delta-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
The cortico-rubral and cerebello-rubral pathways are topographically organized within the human red nucleus
DNA methylome study of human cerebellar tissues identified genes and pathways possibly involved in essential tremor
Pathological ponto-cerebello-thalamo-cortical activations in primary orthostatic tremor during lying and stance
Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature
Brain Metabolic Changes with Longitudinal Transcutaneous Afferent Patterned Stimulation in Essential Tremor Subjects
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