Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease

Nutrition & Metabolism
Hye Jeong YangSunmin Park

Abstract

Dementia induced by β-amyloid accumulation impairs peripheral glucose homeostasis, but red pepper extract improves glucose homeostasis. We therefore evaluated whether long-term oral consumption of different red pepper extracts improves cognitive dysfunction and glucose homeostasis in type 2 diabetic rats with β-amyloid-induced dementia. Male diabetic rats received hippocampal CA1 infusions of β-amyloid (25-35) (AD) or β-amyloid (35-25, non-plaque forming), at a rate of 3.6 nmol/day for 14 days (Non-AD). AD rats were divided into four dietary groups receiving either 1% lyophilized 70% ethanol extracts of either low, moderate and severe pungency red peppers (AD-LP, AD-MP, and AD-SP) or 1% dextrin (AD-CON) in Western diets (43% energy as fat). The ascending order of control < LSP < MSP and SSP potentiated the phosphorylation of CREB and GSK and inhibited Tau phosphorylation in the hippocampus which in turn inhibited β-amyloid accumulation. The inhibition by MP and SP reduced the memory deficit measured by passive avoidance test and water maze test. Furthermore, the accumulation of β-amyloid induced glucose intolerance, although serum insulin levels were elevated during the late phase of oral glucose tolerance test (OGTT). All of t...Continue Reading

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Citations

Jun 11, 2016·Cell Stress & Chaperones·Philip L HooperLászló Vígh
Jan 18, 2017·Journal of Chemical Neuroanatomy·Meha Fatima AftabRizwana S Waraich
May 19, 2018·Nutrients·Sunil K PanchalLindsay Brown
Dec 11, 2019·Drug Development Research·Kavya JashKiran Kalia

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Methods Mentioned

BETA
genetic knockout
pancreatectomy
ELISA
protein assay

Software Mentioned

AmLogger
SAS

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