Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial

BMC Cardiovascular Disorders
Yangjing XueKangting Ji

Abstract

About 10-15% patients who take statins experience skeletal muscle problems. Red yeast rice has a good safety profile could provide a compromise therapeutic strategy. Therefore, the aim of this study was to evaluate the effects of red yeast rice, when compared to simvastatin, on the muscle fatigue symptom and the serum lipid level in dyslipidemic patients with low to moderate cardiovascular risk. A total of 60 dyslipidemic patients with low to moderate cardiovascular risk were recruited and randomly assigned to receive either simvastatin (n = 33) or red yeast rice (n = 27) for 4 weeks. The muscle fatigue score, the physical activity, the serum lipid profile and the safety profile were then evaluated. At the end of study, the fatigue score was significantly increased in patients treated with simvastatin, whereas no significant change was observed in patients receiving red yeast rice. In addition, the physical activity level was significantly decreased in patients from simvastatin group when compared to those from red yeast rice group. Similar lipid-lowering effects were observed in two groups. The safety profile was not affected after the treatments. Among dyslipidemic patients with low to moderate cardiovascular risk, red yeast ...Continue Reading

Associated Clinical Trials

References

May 1, 1974·Clinical Pharmacology and Therapeutics·D R Taves
Apr 3, 2003·Journal of Psychosomatic Research·Helen J MichielsenGuus L Van Heck
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Jun 29, 2005·Applied Microbiology and Biotechnology·Jyh-Jye WangTzu-Ming Pan
Feb 3, 2006·Cardiovascular Drugs and Therapy·Eric BruckertBernard Bégaud
Apr 4, 2006·The American Journal of Cardiology·James M McKenneyUNKNOWN National Lipid Association Statin Safety Assessment Task Force
Jun 28, 2006·International Journal of Clinical Pharmacology and Therapeutics·S DelliauxY Jammes
Aug 4, 2006·American Journal of Physiology. Cell Physiology·Amie J Dirks, Kimberly M Jones
Mar 29, 2008·International Journal of Cardiology·Luca Mascitelli, Francesca Pezzetta
Jun 17, 2009·Circulation·P Michael HoJohn S Rumsfeld
May 27, 2010·Pharmacotherapy·Stephanie ChamBeatrice A Golomb
Jun 30, 2011·European Heart Journal·UNKNOWN European Association for Cardiovascular Prevention & RehabilitationUNKNOWN ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees
Jun 13, 2012·Archives of Internal Medicine·Beatrice A GolombHalbert L White
Nov 8, 2012·Complementary Therapies in Medicine·Clinton W Yang, Shaker A Mousa

❮ Previous
Next ❯

Citations

Sep 27, 2018·BMC Complementary and Alternative Medicine·Napatara TirawanchaiSumate Ampawong
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiawen SongXiaofang Li
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinyu JiYongyan Wang

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American College of Cardiology
Kirti Kain
The Virtual Mentor : VM
David J Becker, Ram Y Gordon
Journal of the American College of Cardiology
Martin Bødtker MortensenErling Falk
© 2022 Meta ULC. All rights reserved