Redefining epilepsy

Current Opinion in Neurology
Robert S Fisher

Abstract

In 2014, the definition of epilepsy was revised by the International League Against Epilepsy (ILAE). A conceptual definition of epilepsy was proposed by the ILAE in 2005, as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures and by its psychosocial consequences. Practical application of the epilepsy definition usually is taken to mean at least two unprovoked seizures more than 24 h apart, but a 2014 practical definition refines the description. With this definition, epilepsy is a disease of the brain with either: (1) at least two unprovoked (or reflex) seizures occurring more than 24 h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals past the applicable age of an age-dependent epilepsy syndrome or those who have remained seizure-free for the past 10 years, with no seizure medicines for the past 5 years. A consensus process has refined the definition of epilepsy.

References

Jul 1, 1991·Epilepsia·W A HauserL T Kurland
Feb 12, 1998·The New England Journal of Medicine·W A HauserV E Anderson
Nov 2, 2002·Neuroepidemiology·Ettore BeghiUNKNOWN Italian ALS Study Group
Aug 7, 2010·Seizure : the Journal of the British Epilepsy Association·Petra M C CallenbachOebele F Brouwer
Sep 28, 2010·Epilepsy & Behavior : E&B·V VillanuevaA Gil-Nagel
Nov 12, 2010·Epilepsia·Sarah E BuckinghamMichael R Sperling
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jun 29, 2011·Annals of Neurology·Anne T BergSusan R Levy
Feb 14, 2012·Journal of Neurosurgery·Nathan C RowlandEdward F Chang
Sep 4, 2012·Handbook of Clinical Neurology·Aidan NeliganJosemir W Sander
Nov 10, 2013·Epilepsia·Eduardo GoellnerDavid A Steven
Apr 16, 2014·Epilepsia·Robert S Fisher
Nov 5, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M Mula, H R Cock
Nov 11, 2014·Epilepsia·Gary W MathernAstrid Nehlig
Nov 11, 2014·Epilepsia·Robert S Fisher
Dec 3, 2014·Epilepsy & Behavior : E&B·Ashish Malkan, Roy G Beran

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Citations

Oct 7, 2015·Epilepsy & Behavior : E&B·Gabriel Perfeito CastroMárcio Flávio Dutra Moraes
Jul 30, 2015·Epilepsy Research·Kyoung Hoon JeongSang Ryong Kim
Aug 24, 2018·Journal of Medicinal Food·Jae Young KwonSang Ryong Kim
Oct 29, 2019·Behavioural Pharmacology·Amal Mohamed Mahfoz, Naiyer Shahzad
Jan 30, 2020·Frontiers in Cellular Neuroscience·Karen M J van Loo, Albert J Becker
Mar 16, 2017·Acta Neurologica Scandinavica·A J NobleA G Marson
Oct 5, 2016·Experimental and Therapeutic Medicine·Liliana Carmona-AparicioNoemí Cárdenas-Rodríguez
Jul 1, 2018·Genes·Esaú Floriano-SánchezNoemí Cárdenas-Rodríguez
Jul 18, 2017·Neurologia i neurochirurgia polska·Dominika GawlakAndrzej Rysz
Aug 14, 2021·Neuroscience and Biobehavioral Reviews·Esther PototskiyAlberto E Musto
Apr 20, 2018·ACS Chemical Neuroscience·Daniëlle CopmansPeter A M de Witte

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