Redefining functional models of basal ganglia organization: role for the posteroventral pallidum in linguistic processing?

Movement Disorders : Official Journal of the Movement Disorder Society
Brooke-Mai WhelanBruce Hall

Abstract

Traditionally the basal ganglia have been implicated in motor behavior, as they are involved in both the execution of automatic actions and the modification of ongoing actions in novel contexts. Corresponding to cognition, the role of the basal ganglia has not been defined as explicitly. Relative to linguistic processes, contemporary theories of subcortical participation in language have endorsed a role for the globus pallidus internus (GPi) in the control of lexical-semantic operations. However, attempts to empirically validate these postulates have been largely limited to neuropsychological investigations of verbal fluency abilities subsequent to pallidotomy. We evaluated the impact of bilateral posteroventral pallidotomy (BPVP) on language function across a range of general and high-level linguistic abilities, and validated/extended working theories of pallidal participation in language. Comprehensive linguistic profiles were compiled up to 1 month before and 3 months after BPVP in 6 subjects with Parkinson's disease (PD). Commensurate linguistic profiles were also gathered over a 3-month period for a nonsurgical control cohort of 16 subjects with PD and a group of 16 non-neurologically impaired controls (NC). Nonparametric ...Continue Reading

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Citations

Oct 18, 2014·Journal of Neurosurgery. Pediatrics·Joseph R KeenFrank P K Hsu
Feb 8, 2006·Parkinsonism & Related Disorders·Mauro César Quintão Silva CunninghamFrancisco Cardoso
Sep 30, 2016·Brain Structure & Function·Christos PliatsikasJames Douglas Saddy
Oct 2, 2015·American Journal of Speech-language Pathology·Ying YangChantel S Prat
May 19, 2007·The Journal of Head Trauma Rehabilitation·Brooke-Mai WhelanNicholas Bellamy

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