Redefining idiopathic interstitial lung disease into occupational lung diseases by analysis of chemical composition of inhaled dust particles in induced sputum and/or lung biopsy specimens

Toxicology and Industrial Health
E M FiremanM R Kramer

Abstract

There has been increased public awareness of the potential danger from exposure to hazardous dust in various occupations. This study aims to validate the qualitative analysis of scanning electron microscopy (SEM) of lung samples by 1) correlation of induced sputum (IS) findings to clinical findings, 2) comparing hazardous particles in IS to those in biopsied lung specimens, and 3) assessing whether the particles present in the lungs of transplanted patients correlate with occupational history of dust exposure. Forty patients with occupational history were included; of whom 35 filled in questionnaires. Twenty-four of them had SEM analysis of their IS, and 11 of these 24 also had SEM analysis of their lung tissue. Another 11 lung biopsies from patients with occupational history were scanned by SEM and compared with 10 lung biopsies from patients with no occupational history. SEM analysis of IS was as efficient for detecting hazardous particles as was SEM analysis of lung tissue; silica was detected better in sputum. Exposure to silica was the main chemical element associated with a high likelihood to show abnormalities in IS (Odds ratio 19.41 CI = 0.270-1398.33). The average number of detected hazardous chemical elements in patie...Continue Reading

References

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Sep 17, 2004·Archives of Environmental Health·Yehuda LermanElizabeth Fireman
Nov 9, 2004·Environmental Health Perspectives·Elizabeth M FiremanDavid J Prezant
Jun 2, 2006·Proceedings of the American Thoracic Society·Varsha S Taskar, David B Coultas
Nov 14, 2006·American Journal of Industrial Medicine·Alexander GuberElizabeth Fireman
Jan 2, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·J AllyW Roa
Feb 28, 2007·Toxicologic Pathology·James C Bonner

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Citations

Mar 28, 2009·Current Opinion in Allergy and Clinical Immunology·Elizabeth Fireman
Sep 29, 2019·Occupational and Environmental Medicine·Noa OphirElizabeth Fireman
Jul 25, 2021·International Journal of Environmental Research and Public Health·Elizabeth FiremanMordechai Reuven Kramer
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology

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