Redefining synchronous colorectal cancers based on tumor clonality

International Journal of Cancer. Journal International Du Cancer
José PereaRogelio González Sarmiento

Abstract

To analyze the possible clonal origin of a part of Synchronous colorectal cancer (SCRC), we studied 104 paired-SCRCs from 52 consecutive patients without hereditary forms of CRC. We used a Single-Nucleotide Polymorphism array to characterize the genomic profiles, and subsequently used a statistical application to define them according to clonality within the same individual. We categorized the ensuing groups according to colonic location to identify differential phenotypes. The SCRC Monoclonal group (M) (19 cases) was divided into Monosegmental (MM) and Pancolonic (MP) groups. The SCRC Polyclonal group (P) (33 cases) was also divided into Monosegmental (PM) and Pancolonic (PP), the first exhibiting preference for left colon. The MM group showed a high rate of mucinous tumors, the lowest mean-number of tumors and associated-polyps, and the worst prognosis. The MP group included the largest mean-number of associated-polyps, best prognosis and familial cancer component. The PM group seemed to be a "frontier" group. Finally, the PP group also exhibited a mucin component, the highest mean-number of tumors (4.6) compared with the mean-number of polyps (7.7), poor prognosis and sporadic cases. Most relevant differential genomic region...Continue Reading

References

Mar 17, 1999·International Journal of Cancer. Journal International Du Cancer·M PedroniM Ponz de Leon
Mar 4, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K EguchiM Tsuneyoshi
Oct 10, 2003·International Journal of Colorectal Disease·Catherine M SuterRobyn L Ward
Feb 19, 2004·Journal of the National Cancer Institute·Asad UmarSudhir Srivastava
Sep 22, 2005·Journal of the National Cancer Institute·Edward Giovannucci, Shuji Ogino
Sep 22, 2005·Journal of the National Cancer Institute·Lanlan ShenJean-Pierre J Issa
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rameen BeroukhimWilliam R Sellers
Jan 1, 2008·The Journal of Molecular Diagnostics : JMD·Shuji Ogino, Ajay Goel
Oct 1, 2009·Gastroenterology·Barbara A Leggett, Daniel L Worthley
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
May 24, 2011·American Journal of Surgery·Alfred King-Yin LamSimon Siu
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
Feb 28, 2013·BMC Genomics·Gro NilsenOle Christian Lingjaerde
Nov 5, 2013·The Journal of Molecular Diagnostics : JMD·José PereaMiguel Urioste
Jun 14, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul LochheadShuji Ogino
Jun 20, 2014·World Journal of Gastroenterology : WJG·Alfred King-Yin LamMelissa Leung
Nov 26, 2015·The Annals of Applied Statistics·Irina OstrovnayaColin B Begg
Dec 22, 2015·World Journal of Gastrointestinal Oncology·José A Pajares, José Perea
Sep 30, 2017·International Journal of Cancer. Journal International Du Cancer·Tomas TanskanenLauri A Aaltonen
Nov 7, 2017·International Journal of Cancer. Journal International Du Cancer·Jiabo DiXiangqian Su

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