PMID: 9418954Jan 7, 1998Paper

Redefining the lipophilin family of proteolipid proteins

Journal of Neuroscience Research
A Gow

Abstract

The past few years have seen a dramatic increase in our understanding, in molecular terms, of the involvement of the central nervous system proteolipid protein in myelinogenesis and X-linked genetic diseases. In addition, we have expanded our knowledge of the proteins that have been recruited into the vertebrate myelin membrane over the past 400 million years with the molecular cloning of several cDNAs encoding proteins which are homologous to the proteolipid protein gene. In searching for a name to distinguish these proteins from other "proteolipid" proteins of nonneural origin I propose that we resurrect the term "lipophilins" which describes a small family of unusually hydrophobic integral membrane proteins exhibiting identical topologies and similar physical properties. Two subgroups are distinguishable among the lipophilins based on the patterns of expression during development and the presence or absence of a small motif that is exposed to the extracellular space.

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Citations

May 1, 2008·Neuron Glia Biology·Robert M GouldAlexander Gow
Jun 18, 2002·Journal of Neurochemistry·M A MoscarelloD D Wood
Jun 17, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephanie HurstAlexander Gow
Jul 22, 1998·Microscopy Research and Technique·R Naef, U Suter
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jian Yi LiWilliam M Pardridge
Dec 16, 2006·Journal of Neuroscience Research·Cherie SouthwoodAlexander Gow
Oct 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Bin LiuTong-Chuan He
Nov 21, 2000·Current Opinion in Neurobiology·J M Bronstein

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