PMID: 11910894DOI: 10.1038/nri721Mar 26, 2002Paper
Redefinition of lymphoid progenitors
Nature Reviews. Immunology
Yoshimoto Katsura
Abstract
Similarities between T and B lymphocytes might have led to the idea that these functionally distinct cells develop from a common lymphoid progenitor. However, investigations with a new clonal assay which allows for T-, B- and myeloid-lineage development indicate that commitment to T-cell and B-cell lineages occurs instead through myeloid/T and myeloid/B bipotential stages, respectively. These findings provide an opportunity to reconsider the ontogeny and phylogeny of T- and B-cell development.
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