Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface

Chemical Science
Bijuan LinShoufa Han

Abstract

Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid (DNPSia). This enables marked suppression of pulmonary metastasis and subcutaneous tumor growth of B16F10 melanoma cells in mice preimmunized to produce anti-DNP antibodies. Located on the exterior glycocalyx, DNPSia is well-positioned to recruit antibodies. Given the high levels of natural anti-DNP antibodies in humans and ubiquitous sialylation across many cancers, DNPSia offers a simplified route to redirect immunity against diverse tumors without recourse to preimmunization.

References

Feb 1, 1976·European Journal of Immunology·K Karjalainen, O Mäkelä
Oct 1, 1991·Current Opinion in Immunology·S Hakomori
Nov 15, 1988·European Journal of Biochemistry·H J Gross, R Brossmer
Mar 17, 2000·Science·E Saxon, C R Bertozzi
Sep 8, 2000·The Journal of Biological Chemistry·T LiuH J Jennings
Aug 15, 2001·European Journal of Biochemistry·C OetkeO T Keppler
Dec 26, 2001·The Journal of Biological Chemistry·Cornelia OetkeMichael Pawlita
Dec 5, 2002·Current Opinion in Structural Biology·Paul R Crocker
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lee M KrugPhilip O Livingston
Mar 5, 2004·Chembiochem : a European Journal of Chemical Biology·Sarah J LuchanskyCarolyn R Bertozzi
Mar 30, 2004·The Journal of Biological Chemistry·Wei ZouHarold J Jennings
May 11, 2004·Cancer Science·Reiji KannagiNaoko Kimura
Aug 20, 2004·Nature·Jennifer A PrescherCarolyn R Bertozzi
Jan 13, 2006·Nature Chemical Biology·Shoufa HanJames C Paulson
Mar 15, 2006·Biochemistry·Peter ChefaloClifford V Harding
Feb 13, 2007·ACS Chemical Biology·Coby B CarlsonLaura L Kiessling
May 29, 2008·Journal of the American Chemical Society·Mary K O'ReillyJames C Paulson
Oct 21, 2009·Journal of the American Chemical Society·Christopher G ParkerDavid A Spiegel
Nov 6, 2009·Journal of the American Chemical Society·Ryan P MurelliDavid A Spiegel
Feb 25, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Richard A MorganSteven A Rosenberg
Apr 16, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·André A NevesKevin M Brindle
Apr 25, 2012·Cancer Immunology, Immunotherapy : CII·Grazyna Lipowska-BhallaDominic G Rothwell
Jun 1, 2012·Journal of the American Chemical Society·Ran XieXing Chen
Jun 12, 2012·Nature Chemical Biology·Cory D RillahanJames C Paulson
Feb 21, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cor Hj LamersJan W Gratama
Sep 24, 2013·ACS Chemical Biology·Charles E JakobscheDavid A Spiegel
Nov 28, 2013·Annual Review of Medicine·David M BarrettCarl H June
Dec 3, 2013·Nature Chemical Biology·Jason E HudakCarolyn R Bertozzi
Dec 18, 2013·Immunological Reviews·Eleanor J CheadleDavid E Gilham
Dec 19, 2013·Nature Chemical Biology·Matthew S Macauley, James C Paulson
May 30, 2014·ACS Chemical Biology·Jonathan M FuraMarcos M Pires
Nov 12, 2014·Nature Reviews. Clinical Oncology·Christopher A KlebanoffNicholas P Restifo

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Citations

Sep 2, 2020·Chemical Communications : Chem Comm·Sang-Hyun ParkInjae Shin
Jan 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhenghuan ZhaoJinhao Gao
Nov 25, 2018·Scientific Reports·Zhongwei XueShoufa Han
Nov 22, 2020·Nature Chemistry·Hua Wang, David J Mooney
Jul 3, 2021·RSC Chemical Biology·Silvia AchilliOlivier Renaudet
May 25, 2018·ACS Chemical Biology·Shanshan LiBinghe Wang
Jan 22, 2022·Dalton Transactions : an International Journal of Inorganic Chemistry·Itziar Galarreta-RodriguezMaite Insausti
Jan 22, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huiling DongXuanjun Wu

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Methods Mentioned

BETA
fluorescence
flow cytometry
enzyme-linked immunosorbent assay
ELISA

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