Redirecting T Cells against Epstein-Barr Virus Infection and Associated Oncogenesis.

Cells
Christian Münz

Abstract

The Epstein-Barr virus (EBV) is associated with lymphomas and carcinomas. For some of these, the adoptive transfer of EBV specific T cells has been therapeutically explored, with clinical success. In order to avoid naturally occurring EBV specific autologous T cell selection from every patient, the transgenic expression of latent and early lytic viral antigen specific T cell receptors (TCRs) to redirect T cells, to target the respective tumors, is being developed. Recent evidence suggests that not only TCRs against transforming latent EBV antigens, but also against early lytic viral gene products, might be protective for the control of EBV infection and associated oncogenesis. At the same time, these approaches might be more selective and cause less collateral damage than targeting general B cell markers with chimeric antigen receptors (CARs). Thus, EBV specific TCR transgenic T cells constitute a promising therapeutic strategy against EBV associated malignancies.

References

Sep 8, 1994·The New England Journal of Medicine·H E HeslopC M Rooney
Oct 13, 1998·Immunity·G J BabcockD A Thorley-Lawson
May 17, 2000·The Journal of Experimental Medicine·C MünzR M Steinman
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·V L CrotzerV H Engelhard
Feb 13, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R J OrentasM I Nishimura
Mar 22, 2002·Nature Reviews. Immunology·D A Thorley-Lawson
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Casper PaludanChristian Münz
Feb 20, 2003·Nature Medicine·Sharof M TugizovJoel M Palefsky
May 1, 1965·The Journal of Experimental Medicine·M A EPSTEINY M BARR
Dec 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Donna HochbergDavid A Thorley-Lawson
Aug 19, 2004·Cell·Almudena R RamiroMichel C Nussenzweig
Dec 23, 2004·Journal of Virology·Lauri L Laichalk, David A Thorley-Lawson
Jan 22, 2005·Annual Review of Medicine·Stephen GottschalkHelen E Heslop
Nov 10, 2005·PLoS Biology·Markus Altmann, Wolfgang Hammerschmidt
Jan 13, 2006·International Journal of Cancer. Journal International Du Cancer·Donald Maxwell Parkin
Nov 28, 2007·Annual Review of Pathology·J L Kutok, F Wang
Apr 8, 2009·The Lancet Oncology·Véronique BouvardUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Jun 3, 2009·The Journal of Experimental Medicine·Till StrowigChristian Münz
Oct 17, 2009·The Journal of Infectious Diseases·Misako YajimaShigeyoshi Fujiwara
May 28, 2010·The New England Journal of Medicine·Katherine Luzuriaga, John L Sullivan
Jan 10, 2012·Annual Review of Immunology·Gabriel D Victora, Michel C Nussenzweig
May 12, 2012·The Lancet Oncology·Catherine de MartelMartyn Plummer
Sep 29, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G FrumentoF E Chen
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vanya IchevaTobias Feuchtinger
Dec 12, 2012·Transplantation·Tilmann SchoberBritta Maecker-Kolhoff
Oct 12, 2013·Annual Review of Pathology·Ethel Cesarman
Dec 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine M BollardCliona M Rooney

❮ Previous
Next ❯

Citations

Dec 5, 2020·Cells·Hans J Stauss, Maxine G B Tran
Mar 7, 2021·Viruses·Marco QuagliaVincenzo Cantaluppi
Mar 23, 2021·Frontiers in Immunology·Darel Martínez BedoyaDenis Migliorini
Jul 10, 2021·Frontiers in Microbiology·Vincent Jean-PierreRaphaële Germi
Jul 27, 2021·Clinics in Laboratory Medicine·Ahmed AljudiSunita Park
Jan 18, 2022·Reviews in Medical Virology·Mahsa MohammadiMohsen Sheykhhasan

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
leukapheresis

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.